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2C-B Synthesis - IceCool - Download as PDF ..

This method is based on the one found in Pihkal #20 for the synthesis of 2C-B

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Erowid Online Books : "PIHKAL" - #32 2C-H

In the functional assay, the N-(2-hydroxybenzyl) substituted compounds generally showedthe highest activity at the 5-HT2A receptor with moderateto good selectivity. With very few exceptions, the intrinsic activitywas above 70% for all compounds on both 5-HT2A and 5-HT2C. N-(2-Methoxybenzyl) compounds (112a) were less active and also less selective5-HT2A agonists. From the N-(2-hydroxybenzyl)compounds, 1b emerged as the most functionally potentof all ligands tested with an EC50 of 0.074 nM with morethan 400-fold selectivity for the 5-HT2A receptor. The N-(2,3-methylenedioxybenzyl) substituted compounds (1d12d) were generally less potent. The N-(2-fluorobenzyl) compounds (1c12c) were inferior in terms of affinity, efficacy, and selectivitycompared to the other three series, mirroring the results from thebinding assays, but comparable to the parent phenethylamines.

The authors suggested that this compound was a by-product of 2C-B synthesis

A total of 60 adult zebrafish ()irrespective of gender (length, 4–5 cm; weight, ~300 mg), werepurchased from Angel Aquarium (Thanjavur, India). The fish were fed, tanks cleaned and sterilized, and water replacedperiodically. Water quality was monitored regularly, and itstemperature was maintained at 25±2°C. The fish were allowed toacclimatize for one week prior to nanoparticle exposure. The fishwere randomly assigned to seven groups: Control group, and groupsexposed to CoO-NPs at 1, 5, 10, 50, 100 and200 ppm concentrations, with six fish in each group (200 ml/tank).All fish studies were conducted in accordance with theinstitutional animal ethics committee recommendations of SASTRAUniversity (Thanjavur, India).

SYNTHESIS: A solution of 50 g 2 ..

2C-H is used as a precursor in the synthesis of other substituted phenethylamines

The resultsfrom the binding affinity measurements showed that the majority ofthe compounds bind to both 5-HT2A and 5-HT2C receptors in the low nanomolar range with several compounds havingsubnanomolar affinities (pKi above 9)at the 5-HT2A receptor. Previously, a smaller subset ofcompounds were subjected to a broader screen which showed the N-benzyl phenethylamines are highly selective for the 5-HT2 receptor subtypes over a wide selection of other neuroreceptors. Ligands substituted with F, CN, or Me at the4-position of the phenethylamine core (4ad, 6ad, and 7ad) have slightly lower affinities which is inaccordance with affinity data published previously on simple/primaryphenethylamines and amphetamines. Ingeneral, the ligands with a N-(2-fluorobenzyl) substituent(1c12c) have lower affinities thanthe other N-benzyl substituents which could be dueto a diminished hydrogen bond acceptor capability.

tsA201cells (a transformed HEK293 cell line) were cultured in GlutaMAX-IDulbecco’s modified Eagle’s medium (DMEM) supplementedwith 10% dialyzed fetal bovine serum, penicillin (100 U mL–1), and streptomycin (100 mg mL–1) at 37 °Cin a humidified atmosphere of 95% air and 5% CO2. Constructsencoding human 5-HT2A and 5-HT2C in pcDNA3.1were obtained from the Missouri S&T cDNA Resource Center () and transiently transfected into cells usingPolyFect according to the manufacturer’s protocol (Qiagen,West Sussex, U.K.).

Improved Bromination of 2C-H to 2C-B·HBr - …

The following is a synthesis of 2C-B from 2,5-dimethoxybenzaldehyde that does not require the use of the slightly hazardous and/or ..

History. 2C-H was first synthesized in 1932 by Johannes S. Buck. Usage. 2C-H is used as a precursor in the synthesis of other substituted phenethylamines.
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  • now this is toluene containing 2C-H freebase

    2C-B synthesis without LAH

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    (2C-H) spontaneously ..

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    2C-H - Wikipedia

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