2C-B Synthesis - IceCool - Download as PDF ..
This method is based on the one found in Pihkal #20 for the synthesis of 2C-B
Erowid Online Books : "PIHKAL" - #32 2C-H
In the functional assay, the N-(2-hydroxybenzyl) substituted compounds generally showedthe highest activity at the 5-HT2A receptor with moderateto good selectivity. With very few exceptions, the intrinsic activitywas above 70% for all compounds on both 5-HT2A and 5-HT2C. N-(2-Methoxybenzyl) compounds (1–12a) were less active and also less selective5-HT2A agonists. From the N-(2-hydroxybenzyl)compounds, 1b emerged as the most functionally potentof all ligands tested with an EC50 of 0.074 nM with morethan 400-fold selectivity for the 5-HT2A receptor. The N-(2,3-methylenedioxybenzyl) substituted compounds (1d–12d) were generally less potent. The N-(2-fluorobenzyl) compounds (1c–12c) were inferior in terms of affinity, efficacy, and selectivitycompared to the other three series, mirroring the results from thebinding assays, but comparable to the parent phenethylamines.
A total of 60 adult zebrafish ()irrespective of gender (length, 4–5 cm; weight, ~300 mg), werepurchased from Angel Aquarium (Thanjavur, India). The fish were fed, tanks cleaned and sterilized, and water replacedperiodically. Water quality was monitored regularly, and itstemperature was maintained at 25±2°C. The fish were allowed toacclimatize for one week prior to nanoparticle exposure. The fishwere randomly assigned to seven groups: Control group, and groupsexposed to CoO-NPs at 1, 5, 10, 50, 100 and200 ppm concentrations, with six fish in each group (200 ml/tank).All fish studies were conducted in accordance with theinstitutional animal ethics committee recommendations of SASTRAUniversity (Thanjavur, India).
SYNTHESIS: A solution of 50 g 2 ..
The resultsfrom the binding affinity measurements showed that the majority ofthe compounds bind to both 5-HT2A and 5-HT2C receptors in the low nanomolar range with several compounds havingsubnanomolar affinities (pKi above 9)at the 5-HT2A receptor. Previously, a smaller subset ofcompounds were subjected to a broader screen which showed the N-benzyl phenethylamines are highly selective for the 5-HT2 receptor subtypes over a wide selection of other neuroreceptors. Ligands substituted with F, CN, or Me at the4-position of the phenethylamine core (4a–d, 6a–d, and 7a–d) have slightly lower affinities which is inaccordance with affinity data published previously on simple/primaryphenethylamines and amphetamines. Ingeneral, the ligands with a N-(2-fluorobenzyl) substituent(1c–12c) have lower affinities thanthe other N-benzyl substituents which could be dueto a diminished hydrogen bond acceptor capability.
tsA201cells (a transformed HEK293 cell line) were cultured in GlutaMAX-IDulbecco’s modified Eagle’s medium (DMEM) supplementedwith 10% dialyzed fetal bovine serum, penicillin (100 U mL–1), and streptomycin (100 mg mL–1) at 37 °Cin a humidified atmosphere of 95% air and 5% CO2. Constructsencoding human 5-HT2A and 5-HT2C in pcDNA3.1were obtained from the Missouri S&T cDNA Resource Center () and transiently transfected into cells usingPolyFect according to the manufacturer’s protocol (Qiagen,West Sussex, U.K.).
Improved Bromination of 2C-H to 2C-B·HBr - …
of drugs is 2C-I > 2C-B > 2C-D > 2C-H
now this is toluene containing 2C-H freebase
2C-B synthesis without LAH
2C-B - an overview | ScienceDirect Topics
(2C-H) spontaneously ..
described a GC/MS protocol for analysis of 2C-B, 2C-H, 2C-I ..
2C-H - Wikipedia
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