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A simple, efficient synthesis of 2-aryl benzimidazoles using silica supported periodic Acid catalyst and ..

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Quinazoline synthesis - Organic Chemistry Portal

We report the synthesis of benzimidazoles using lanthanum chloride as an efficient catalyst. One-pot synthesis of 2-substituted benzimidazole derivatives from o-phenylenediamine and a variety of aldehydes were developed under mild reaction conditions.

21/06/2010 · Concise copper-catalyzed one-pot tandem synthesis of benzimidazo[1,2 ..

Mobinikhaledi A, Foroughifar N, Khajeh-Amiri A. N-Propylcarbamothioyl benzamide complex of Bi(III) supported on superparamagnetic Fe3O4/SiO2 nanoparticles as a highly efficient and magnetically recoverable heterogeneous nanocatalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) via the Biginelli reaction. Reaction Kinetics, Mechanisms and Catalysis 2015;41(1):59-75.

Aerobic Copper-Catalyzed Organic Reactions - …

“An Efficient and Inexpensive Synthesis of 2-Substituted Benzimidazoles in Water ..

An efficient one-pot, three-component synthesis of 2-imino-1,3-thiazolidines and 2-imino-1,3-thiazolines using ionic liquid-tethered 2-aminobenzimidazoles was reported. The protocol includes reaction of ionic liquid attached 2-aminobenzimidazoles with isothiocyanates to afford isothioureas, followed by its base induced inter and intramolecular nucleophilic displacement reactions with 1,2-dichloroethane (EDC) which results in thiazolidine ring formation. In the next to the last step, the ionic liquid support was removed by methanolysis to deliver 2-imino-1,3-thiazolidines, which were sequentially oxidized with manganese(III) triacetate to yield 2-imino-1,3-thiazolines. The salient feature of this method is the use of 1,2-dichloroethane as a synthetic equivalent for α-haloketone to avoid the use of toxic halogenating reagents.

Herein, we describe a simple, highly efficient and environmentally friendly protocol for the synthesis of benzimidazoles, benzoxazoles, benzothiazoles, 3,4-dihydropyrimidin-2-ones/ thiones and quinoxalines derivatives using hybrid crystal NH3(CH2)6NH3SiF6 as a catalyst. Use of recyclable catalyst, easy work-up procedure, excellent yields, short reaction times and scalability are the important practical features of the present protocol.

PDF Downloads : Oriental Journal of Chemistry

Beheshtiha YS, Heravi MM, Saeedi M, Karimi N, Zakeri M, Hossieni NT. Efficient and Green Synthesis of 1,2-Disubstituted Benzimidazoles and Quinoxalines Using Br⊘nsted Acid Ionic Liquid, [(CH2)4SO3HMIM][HSO4], in Water at Room Temperature. Synthetic Communications 2010;8(8):1216-1223.

A simple, one-pot and copper-catalyzed coupling reaction for the construction of 1,2-disubstituted benzimidazole derivatives is described. A low-cost copper salt and a weak base K3PO4 were utilized in this reaction. A variety of 1,2-disubstituted benzimidazoles were obtained in moderate to excellent yields.

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  • Synthesis of benzimidazoles - Organic Chemistry Portal

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  • 2-alkyl substituted benzimidazoles ..

    Cu/TEMPO catalyst systems show reduced reactivity in aerobic oxidation of aliphatic and secondary alcohols

  • Thieme E-Journals - Synthesis / Abstract

    Categories: Synthesis of N-Heterocycles > benzo-fused N-Heterocycles > Synthesis of quinazolines

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Thieme E-Books & E-Journals

A simple and one-pot synthesis of multisubstituted benzimidazoles by a Ugi 4CC/catalytic aza-Wittig sequence was developed. The reaction of 2-aminobenzoyl azide 2, aldehyde 3, acid 4, and isocyanide 5 produced the benzimidazoles 8 in moderate to good yields via a sequential Ugi condensation and catalytic aza-Wittig in the presence of a catalytic amount of phospholene oxide.

A simple and efficient method for the synthesis of …

Herein is reported a simple and efficient one-pot three-component synthesis of pyrrolo[1,2-]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones, and electron deficient alkynes in epoxides acting both as reaction medium and HBr scavanger. This method proved to be very lucrative and avoids formation of ylide inactivation products. The synthesis represents an environmentally benign alternative to classical methods. The new library of compounds was briefly characterized regarding the improved Lipinski rule to asses the potential drug-likeness of the compounds. The majority of compounds are statisfing the Lipinski rule.

the efficient, one-pot, three component synthesis of ..

A simple and efficient procedure for the synthesis of substituted benzimidazoles through a one-pot condensation of o-phenylenediamines with aryl aldehydes in the presence of H2O2/HCl system in acetonitrile at room temperature is described. Short reaction time, large-scale synthesis, easy and quick isolation of the products, and excellent yields are the main advantages of this procedure.

synthesis of highly substituted imidazoles ..

Abbasi M. 1,3-Disulfonic acid benzimidazolium chloride as an efficient and recyclable ionic liquid catalyst for the synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones. Research on Chemical Intermediates 2015;25(4):3303-3314.

An Efficient Synthesis of 2-Substituted Benzimidazoles …

A new, efficient method for the synthesis of 2-aryl substituted benzimidazole by using silica supported periodic acid (H5IO6-SiO2) as a catalyst has been developed. The salient feature of the present method includes mild reaction condition, short reaction time, high yield and easy workup procedure. The synthesized benzimidazoles exhibited potent anticancer activity against MCF7 and HL60 cell lines.

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