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(iii) Metabolism of benzyl alcohol, benzoic acid, and related esters

Flavouring ingredientBenzyl alcohol is a colorless liquid with a mild pleasant aromatic odor.

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(iv) Metabolism of substituted benzyl alcohols and benzaldehydes



Molar mass

Benzylalcohol

108 g/mol

Benzoic acid

122 g/mol

Initial amount of benzylalcohol: [IMAGE]

Benzyl alcohol synthesis by benzylic substitution
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Benzoic acid (C7H6O2) is a weak carboxylic acid (contains an OOH functional group), which consists of an aromatic ring and is naturally used as a food preservative, therefore its capable of slowing down/halting the growth rate of bacteria that inhibit most foods.

Synthesis description for preparation of BENZYL ALCOHOL

Other areas of application for benzyl alcohol include cosmetics and personal care formulations as well as coatings and lacquers.
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The ingredients in the clay included benzyl alcohol. Now I will check every cosmetic and med for this ingredient and will do so even if getting salon care. This "safe" preservative should be more comprehensively tested and regulated since even a very small amount of an allergen can trigger a reaction.

The reaction between TiCl4 and benzyl alcohol is a simple and nonaqueous procedure for the synthesis of highly crystalline titania nanoparticles at temperatures as low as 40 °C. XRD measurements prove the exclusive presence of the anatase phase. The particle growth depends strongly on temperature so that with the appropriate thermal conditions the particle size can be selectively adjusted in the range of 4−8 nm. Fine-tuning of the particle size is possible by a proper choice of the relative amounts of benzyl alcohol and titanium tetrachloride. Lowering the titanium tetrachloride concentration leads to a considerable decrease of particle size. BET measurements show particularly high surface areas, up to 345 m2/g for the smallest particles and 115 m2/g for the calcined material. TEM investigations reveal that the nanoparticles are nearly uniform in size and shape. The as-synthesized particles display only minor agglomeration, whereas the calcined material consists of completely nonagglomerated particles, with diameters ranging from 13 to 20 nm. The smallest particles are soluble in a THF/trioctylphosphine mixture that luminesces (425 nm) upon UV irradiation.

Preparation of Benzaldehyde from Benzyl Alcohol

I saw a product that contained Benzyl Alcohol, but said it was plant derived. Is it any less toxic and would you avoid this product? Thank you.
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Benzyl esters and acetals are hydrolysed to benzyl alcohol and carboxylic acids and to benzaldehyde and alcohols, respectively. Benzyl alcohol and benzaldehyde are rapidly oxidized to benzoic acid, while benzoate esters are hydrolysed to benzoic acid and alcohols. The benzoic acid derivatives are excreted primarily as glycine conjugates. Benzoic acid is readily conjugated with glycine, primarily in the liver (see Figure 1). After high doses, formation of the glycine conjugate is limited by the concentration of glycine. When glycine is depleted, free benzoic acid may sequester acetyl coenzyme A or be excreted unchanged or as the glucuronic acid conjugate (Diack & Lewis, 1928; Bray et al., 1951; Williams, 1959; Abdo & Wenk, 1995; Abdo et al., 1998). The metabolism, including hydrolysis, of flavouring agents that were not reviewed by the Committee at its forty-sixth meeting is summarized below.

The benzyl derivatives are rapidly absorbed through the gut, metabolized primarily in the liver, and excreted in the urine as glycine conjugates of benzoic acid derivatives (Davison, 1971; Abdo et al., 1985; Temellini, 1993), as discussed by the Committee at its forty-sixth meeting, when it evaluated benzyl alcohol (No. 25), benzyl acetate (No.23), benzaldehyde (No. 22), and benzoic acid (No. 850) (Annex 1, reference ). After absorption, benzyl derivatives are metabolized and excreted within 24 h as polar metabolites, mainly as urinary hippuric acid (Table 3).

Benzyl alcohol is also a precursor to a variety of esters, used in the manufacture of soap, perfume and flavors.
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  • Benzyl alcohol for synthesis | VWR

    Benzyl alcohol is an aromatic alcohol with the formula C 6 H 5 CH 2 OH

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    12/01/2006 · I try to find the synthesis of benzyl alcohol, but I can't get it

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    Can some one show me how to do the synthesis of benzyl alcohol, in detail

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Benzyl alcohol-based synthesis of oxide nanoparticles: …

Moreno, O.M. (1973) Acute oral toxicity in rats. Dermal toxicity in rabbits. Cuminyl alcohol, tolyl aldehyde, geranyl benzoate, benzyl propionate, benzyl butyrate, linalyl benzoate. Unpublished report No. MB 73-233, MB 73-204, MB 73-94, MB 73-139, MB 72-7, MB 73-98 from MB Research Laboratories, Inc., Perkasie, USA. Submitted to WHO by Flavor and Extracts Manufacturers Association of the United States.

4-(Trifluoromethyl)-benzyl alcohol for synthesis | VWR

LeBel, M., Ferron, L., Masson, M., Pichette, J. & Carrier, C. (1988) Benzyl alcohol metabolism and elimination in neonates. , 11, 347–356.

Benzyl alcohol CAS 100-51-6 | 100987 - Merck Millipore

This is fragrance grade material of high purity: when benzyl alcohol develops a distinct almond note it is due to the formation of benzaldehyde – if this happens discard it and buy fresh.

Distributor of Benzyl Alcohol. - ECEM European …

KalamaTMBenzyl alcohol is used as an intermediate in the synthesis of polypeptides and is used extensively as a non-reactive diluent in epoxy resin coatings, where it reduces the viscosity and raises product flexibility.

Preparation of Benzyl Alcohol and Benzoic Acid - …

At its forty-sixth meeting, the Committtee reviewed a series of studies of developmental and reproductive toxicity with benzyl alcohol (No. 25), benzyl acetate (No. 23), benzyl aldehyde (No. 22), and sodium benzoate (Annex 1, reference ). The Committee concluded that: "Delayed development and reduced fetal and postnatal pup body weights were observed in developmental toxicity studies in rats, mice, hamsters and rabbits, but only at doses that were toxic to the mother. In a teratogenicity study with sodium benzoate, doses that induced severe maternal toxicity were associated with embryotoxic and fetotoxic effects and fetal malformations. A 4-generation study in rats showed no effect on growth, fertility, lactation or survival". The Committee concluded that the data reviewed were sufficient to demonstrate a lack of teratogenic and reproductive potential. No further studies on reproductive toxicity with benzyl derivatives in the group were available for review by the Committee at its present meeting.

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