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Wet chemical synthesis of chitosan …

Wet chemical synthesis of chitosan hydrogel–hydroxyapatite composite membranes for tissue engineering applications

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Chemical Synthesis, Characterization, and …

AB - Novel chitosan gel beads were synthesized by a coupled ionic and chemical co-crosslinking mechanism. Tripolyphosphate (TPP) and a naturally occurring crosslinking reagent, genipin, which has been used in herbal medicine, were employed, respectively, as an ionic and a chemical crosslinkers to prepare the chitosan-based networks of gel beads. The competitive crosslinking of chitosan with ionic crosslinker (TPP) and chemical crosslinker (genipin) was characterized by FTIR, UV and EDAX spectroscopy (X-ray energy dispersion) spectroscopy. The variation of characteristic peak of genipin observed from UV spectroscopy and the characteristic peak of tripolyphosphate in crosslinked chitosan-based networks observed from FTIR spectroscopy suggests that the co-crosslinking mechanism is dependent on the pH of TPP/genipin co-crosslinker. The energy profiles of carbon and phosphorus estimated from confirms that chemical crosslinking dominates the co-crosslinking reaction at higher pH condition (pH 7,0 and 9.0) and ionic crosslinking dominates the co-crosslinking reaction at lower pH condition (pH 1.0, 3.0 and 5.0). The pH-dependent ionic/chemical co-crosslinking mechanism shows an obvious effect on the swelling property and enzymatic degradation behavior of prepared chitosan networks. These results reveal that the ionic/chemical co-crosslinked chitosan networks may be suitable for biomedical applications.

01/07/2009 · Chitosan based oligoamine polymers: synthesis, characterization, ..

N2 - We developed microfluidic-based pure chitosan microfibers (∼1 meter long, 70-150 μm diameter) for liver tissue engineering applications. Despite the potential of the chitosan for creating bio-artificial liver chips, its major limitation is the inability to fabricate pure chitosan-based microstructures with controlled shapes because of the mechanical weakness of the pure chitosan. Previous studies have shown that chitosan micro/nanofibers can be fabricated by using chemicals and electrospinning techniques. However, there is no paper regarding pure chitosan-based microfibers in a microfluidic device. This paper suggests a unique method to fabricate pure chitosan microfibers without any chemical additive. We also analyzed the chemical, mechanical, and diffusion properties of pure chitosan microfibers. Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectrometry and electron spectroscopy for chemical analysis (ESCA) were used to analyze the chemical composition of the synthesized chitosan microfibers. We measured the mechanical axial-force and diffusion coefficient in pure chitosan-based microfibers using fluorescence recovery after photobleaching (FRAP) techniques. Furthermore, to evaluate the capability of the microfibers for liver tissue formation, hepatoma HepG2 cells were seeded onto the chitosan microfibers. The functionality of these hepatic cells cultured on chitosan microfibers was analyzed by measuring albumin secretion and urea synthesis. Therefore, this pure chitosan-based microfiber chip could be a potentially useful method for liver tissue engineering applications.

A series of chitosan-based oligoamine polymers ..

01/03/2009 · Wet chemical synthesis of chitosan hydrogel-hydroxyapatite composite membranes for tissue engineering applications

Novel chitosan gel beads were synthesized by a coupled ionic and chemical co-crosslinking mechanism. Tripolyphosphate (TPP) and a naturally occurring crosslinking reagent, genipin, which has been used in herbal medicine, were employed, respectively, as an ionic and a chemical crosslinkers to prepare the chitosan-based networks of gel beads. The competitive crosslinking of chitosan with ionic crosslinker (TPP) and chemical crosslinker (genipin) was characterized by FTIR, UV and EDAX spectroscopy (X-ray energy dispersion) spectroscopy. The variation of characteristic peak of genipin observed from UV spectroscopy and the characteristic peak of tripolyphosphate in crosslinked chitosan-based networks observed from FTIR spectroscopy suggests that the co-crosslinking mechanism is dependent on the pH of TPP/genipin co-crosslinker. The energy profiles of carbon and phosphorus estimated from confirms that chemical crosslinking dominates the co-crosslinking reaction at higher pH condition (pH 7,0 and 9.0) and ionic crosslinking dominates the co-crosslinking reaction at lower pH condition (pH 1.0, 3.0 and 5.0). The pH-dependent ionic/chemical co-crosslinking mechanism shows an obvious effect on the swelling property and enzymatic degradation behavior of prepared chitosan networks. These results reveal that the ionic/chemical co-crosslinked chitosan networks may be suitable for biomedical applications.

N2 - Novel chitosan gel beads were synthesized by a coupled ionic and chemical co-crosslinking mechanism. Tripolyphosphate (TPP) and a naturally occurring crosslinking reagent, genipin, which has been used in herbal medicine, were employed, respectively, as an ionic and a chemical crosslinkers to prepare the chitosan-based networks of gel beads. The competitive crosslinking of chitosan with ionic crosslinker (TPP) and chemical crosslinker (genipin) was characterized by FTIR, UV and EDAX spectroscopy (X-ray energy dispersion) spectroscopy. The variation of characteristic peak of genipin observed from UV spectroscopy and the characteristic peak of tripolyphosphate in crosslinked chitosan-based networks observed from FTIR spectroscopy suggests that the co-crosslinking mechanism is dependent on the pH of TPP/genipin co-crosslinker. The energy profiles of carbon and phosphorus estimated from confirms that chemical crosslinking dominates the co-crosslinking reaction at higher pH condition (pH 7,0 and 9.0) and ionic crosslinking dominates the co-crosslinking reaction at lower pH condition (pH 1.0, 3.0 and 5.0). The pH-dependent ionic/chemical co-crosslinking mechanism shows an obvious effect on the swelling property and enzymatic degradation behavior of prepared chitosan networks. These results reveal that the ionic/chemical co-crosslinked chitosan networks may be suitable for biomedical applications.

Ethylenediamines/chemical synthesis;

GomesNovel highly soluble peptide–chitosan polymers: chemical synthesis and spectral characterization.

We developed microfluidic-based pure chitosan microfibers (∼1 meter long, 70-150 μm diameter) for liver tissue engineering applications. Despite the potential of the chitosan for creating bio-artificial liver chips, its major limitation is the inability to fabricate pure chitosan-based microstructures with controlled shapes because of the mechanical weakness of the pure chitosan. Previous studies have shown that chitosan micro/nanofibers can be fabricated by using chemicals and electrospinning techniques. However, there is no paper regarding pure chitosan-based microfibers in a microfluidic device. This paper suggests a unique method to fabricate pure chitosan microfibers without any chemical additive. We also analyzed the chemical, mechanical, and diffusion properties of pure chitosan microfibers. Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectrometry and electron spectroscopy for chemical analysis (ESCA) were used to analyze the chemical composition of the synthesized chitosan microfibers. We measured the mechanical axial-force and diffusion coefficient in pure chitosan-based microfibers using fluorescence recovery after photobleaching (FRAP) techniques. Furthermore, to evaluate the capability of the microfibers for liver tissue formation, hepatoma HepG2 cells were seeded onto the chitosan microfibers. The functionality of these hepatic cells cultured on chitosan microfibers was analyzed by measuring albumin secretion and urea synthesis. Therefore, this pure chitosan-based microfiber chip could be a potentially useful method for liver tissue engineering applications.

AB - We developed microfluidic-based pure chitosan microfibers (∼1 meter long, 70-150 μm diameter) for liver tissue engineering applications. Despite the potential of the chitosan for creating bio-artificial liver chips, its major limitation is the inability to fabricate pure chitosan-based microstructures with controlled shapes because of the mechanical weakness of the pure chitosan. Previous studies have shown that chitosan micro/nanofibers can be fabricated by using chemicals and electrospinning techniques. However, there is no paper regarding pure chitosan-based microfibers in a microfluidic device. This paper suggests a unique method to fabricate pure chitosan microfibers without any chemical additive. We also analyzed the chemical, mechanical, and diffusion properties of pure chitosan microfibers. Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectrometry and electron spectroscopy for chemical analysis (ESCA) were used to analyze the chemical composition of the synthesized chitosan microfibers. We measured the mechanical axial-force and diffusion coefficient in pure chitosan-based microfibers using fluorescence recovery after photobleaching (FRAP) techniques. Furthermore, to evaluate the capability of the microfibers for liver tissue formation, hepatoma HepG2 cells were seeded onto the chitosan microfibers. The functionality of these hepatic cells cultured on chitosan microfibers was analyzed by measuring albumin secretion and urea synthesis. Therefore, this pure chitosan-based microfiber chip could be a potentially useful method for liver tissue engineering applications.

Cite this article: DING Shan,TANG Min-Jian,ZHOU Chang-Ren et al. Synthesis and Properties of Cholesterol Graft Chitosan[J]. Chemical Journal …
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Chitosan/polyethylene glycol fumarate blend film: …

Chemical vectors for gene delivery based on only one kind of pure materials, such as lipid or chitosan, have not only their special advantages but also their intrinsic deficiencies which are difficult to resolve. To improve the transfection efficiency and reduce the cytotoxicity, many researchers have focused on combining two or more kinds of materials to enhance the transfection efficiency and at the same time avoiding the side effects to the cells []. Dendron-bearing lipids with PAMAM G1 designated as DL-G1-2C18 have been synthesized. In spite of less efficient cellular uptake of the lipoplexes, they generated free pDNA molecules in the cytosol more effectively than other lipoplexes did [].

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