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Collagen Synthesis - News Medical

T1 - Effects of methylprednisolone on collagen biosynthesis in healing acute myocardial infarction

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What Is Collagen Synthesis? | Healthy Living

Bacteria need to synthesize proteins in order to ensure their reproduction. This biological activity requires the capture of nutrients from the surrounding environment at the expense of the host. Among those nutrients are the amino acids, which are incorporated in the bacteria's ribosomes, the cell organites where protein synthesis takes place.

Mutations in Collagen Reveal Aspects of Its Structure and Biosynthesis

Vitamin C is certainly helpful for collagen health, but it is unclear whether additional Vitamin C will make much of a difference if someone already has a healthy diet with plenty of fresh vegetables and fruits.

Collagens—structure, function, and biosynthesis

In addition high dose vitamin C, in the region of 2-4 grams a day, may also be useful as it assists collagen in its functioning.

CH-Alpha is a liquid in a vial providing 10 grams of collagen hydrolysate, a collection of proteins and amino acids (the building blocks necessary for joint health).

The objective of this postmarketing surveillance study was to determine whether oral use of Collagen Hydrolysate CH-Alpha in athletically active individuals suffering from arthralgia induced by high-intensity athletic activity confers benefit in terms of improvement in pain, functional limitations, or inflammatory activity.

Collagen - Biosynthesis and Degradation - YouTube

CH-Alpha is a natural product with an amino acid composition nearly identical to the collagen found in the extracellular matrix in joints.

The mechanism of HYD-dependent stimulation of prolidase activity may undergo indirectly and may involve IGF-IR. In patients, HYD is known to upregulate 964 genes. Some of them produce proteins of MAPK signaling (De la Cruz-Hernández et al. ). However, increase in the expression of IGF-IR was independent of FAK and MAP kinase (ERK1 and ERK2) expression. Therefore, we suggest that the HYD-dependent increase of collagen biosynthesis in cultured human skin fibroblasts results from the activation of IGF-IR expression and prolidase activity and downregulation of NF-κB p65.

Prolidase catalyzes the final step in collagen degradation which completes the recycling of proline for collagen resynthesis (Jackson and Heininger ; Yaron and Naider ). The best and most abundant substrate for prolidase is glycyl-proline (Gly-Pro). Collagen represent polypeptide containing the highest amount of imido bonds compared to all known proteins. In α1 chains of type I collagen, Gly-Pro occurs 25 times (Jackson et al. ). Therefore, HYD-induced prolidase activity may represent one of the mechanisms of collagen biosynthesis regulation. The functional link between collagen and prolidase activity has been also found in cultured human skin fibroblasts treated with anti-inflammatory drugs (Miltyk et al. ), pyrroline-5-carboxylate (Miltyk and Palka ), during experimental aging of these cells (Palka et al. ), fibroblast chemotaxis (Palka et al. ), and cell surface integrin receptor ligation (Palka and Phang ).

The contents of type I collagen and glycosaminoglycan in the epiphysis were increased by administering shark skin gelatin.
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  • Collagens—structure, function, and biosynthesis ..

    Differential effects of estradiol and raloxifene on collagen biosynthesis in cultured human skin fibroblasts.

  • Impaired Collagen Biosynthesis and Cross-linking in …

    Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen.


    However, I read reports that it's useless since the collagen will only be broken down into amino acids in the stomach.

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Role of vitamin C in collagen biosynthesis and …

In view of this data, it seems that the increase of collagen biosynthesis caused by HYD may be a consequence of increase in IGF-I receptor signaling, prolidase activity and decrease in expression of NF-κB p65.

Role of vitamin C in collagen biosynthesis and connective tissue ..

The increase in collagen biosynthesis in HYD-treated fibroblasts was unrelated to cell proliferation. In fact, it was correlated to the slight decrease in DNA biosynthesis (Fig. ) and MAP kinases, ERK1/2 (Fig. ), compared to control. Moreover, cell viability was measured by the method of Carmichael et al. () using tetrazolinum salt. The viability of cells incubated for 24 h with indicated concentrations of HYD is presented on Fig. . HYD did not influence the viability of the cells. The stability of cells in respect to the rate of proliferation and cell viability may result from experimental model of confluent cells.

collagen biosynthesis and connective tissue health

The finding that HYD causes changes in collagen metabolism led us to investigate the mechanism of its action on collagen biosynthesis in fibroblasts—the main collagen-synthesizing cells (Makela et al. ). The drug induces hypertrophy in the myocardium after infarction in rats (Leite et al. ). Although several studies on animal models have shown that HYD treatment reduces fibrosis in some tissues, it cannot correspond to reduced collagen synthesis. Upregulation of collagen synthesis may reflect interstitial remodeling leading to increase or decrease of tissue collagen content depending on the rate of collagen degradation. It was supported by some studies showing HYD-dependent increase in type III collagen content in myocardium. An example is the paper of Tsotetsi et al. (). Conflicting results were obtained by Murad et al. (), however, in different experimental conditions, including prolonged time of incubation.

CiteSeerX — Collagen Biosynthesis

To explain the mechanism of this process, we considered prolidase as a target enzyme. Increase in collagen biosynthesis in HYD-treated cells was correlated to the increase in prolidase activity (Fig. ). It was accompanied by an increase in prolidase expression (Fig. ) and decrease in prolidase phosphorylation (Fig. ). Moreover, HYD-treated cells contained more free proline (about 15 μM) compared to control cells (about 11 μM) as detected by Chinard assay (data not shown).

Collagen Biosynthesis in Human Oral Submucous …

Our studies suggest potential mechanism for HYD-dependent effect on collagen biosynthesis. The specificity of HYD on collagen biosynthesis was corroborated by parallel experiments with CAP, another hypotensive drug that, in presented experimental conditions, had no effect on the process. It was confirmed in our previous studies (Karna et al. ).

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