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Inhibit DNA synthesis by binding the DNA.

Selectively inhibit RNA synthesis (specially rRNA synthesis) by binding to the DNA.

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Metabolized in vivo into 5-FU and inhibit DNA synthesis.

Therefore, one possible strategy to prevent protein misfolding is to carry out synthesis in the presence of specific substrates or modulators of the protein.

Exhibit an antitumor activity by inhibiting DNA synthesis and cleaving DNA strands.
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The large number of poorly inserting TM segments in P-gp may also explain why multiple topologies have been detected during synthesis and why the translation rate could alter its topology and change P-gp substrate specificity .

In particular,strongly inhibit DNA synthesis.

Metabolized in vivo into 5-FU and inhibit DNA synthesis.
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Mis-processed mutants of the human P-glycoprotein are retained in the endoplasmic reticulum as core-glycosylated biosynthetic intermediates and rapidly degraded.

Synthesis of the mutant proteins in the presence of drug substrates or modulators such as capsaicin, cyclosporin, vinblastine, or verapamil, however, resulted in the appearance of a fully glycosylated and functional protein at the cell surface.

Metabolized in vivo into 5-FU and inhibit DNA synthesis.

The metabolite inhibits DNA synthesis by inhibiting thymidylate synthase.
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Rescue of ΔF508-CFTR by suppressors required the biosynthesis of the entire full-length protein in continuity, as it did not occur when N- and C-terminal "halves" were coexpressed.

This mutation causes the loss of CFTR Cl- channel activity by disrupting biosynthetic processing so that mutant protein does not reach the plasma membrane.

Inhibit nucleic acid (DNA) synthesis by binding to inosinic acid (IMP).
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  • Substrate for FDG-synthesis for PET diagnosis: Mannose Triflate

    Inhibit enzyme activity and purine synthesis by tightly binding to the active folate producing enzyme.

  • for later steps in the biosynthesis of CFTR.

    The antibiotic blocked DNA synthesis more markedly than RNA and protein syntheses.

  • Drug conjugation Services - Bio-Synthesis, Inc.

    The degree of inhibition was stronger with prolongation of incubation period and with increase of DNA synthesis rate.

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developed at Bio-Synthesis using unique conjugation ..

In contrast, the effect of etoposide was not prevented by preincubation of HL-60 cells with the RNA synthesis inhibitor 5,6-dichloro-1-β-ribofuranoylbenzimidazole or the protein synthesis inhibitors cycloheximide or puromycin.

Novabiochem Peptide and DNA Synthesis Reagents; Solvents; ..

In the synchronized cells, strong inhibition of DNA synthesis was observed when geldanamycin was introduced into the culture prior to S phase of the cell cycle.

Biosynthesis of Colchicine - [PDF Document]

Because verapamil is the most potent stimulator of P-gp ATPase activity, we synthesized a thiol-reactive analog of verapamil (MTS-verapamil) and used it with cysteine-scanning mutagenesis to identify the reactive residues within the drug-binding domain of P-gp.

Inhibit DNA synthesis followed by cell division

The presence of a processing mutation (G268V/L443C(NBD1)/S909C(TMD2); L1260A/A266C(TMD1)/F1086C(NBD2)) resulted in the synthesis of the immature (150 kDa) protein as the major product and the mutants could not be cross-linked with copper phenanthroline.

24/12/2017 · GeneArt Gene Synthesis ..

A potential novel strategy to circumvent the effects of P-gp during chemotherapy is to prevent maturation of P-gp during biosynthesis so that the transporter does not reach the cell surface.

custom synthesis of medicinal novel building blocks, ..

which domains of the in vitro synthesized Pgp had transversed the RM membranes by analyzing their resistance to protease digestion and their glycosylation state.

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