scs, succinyl-CoA synthetase; and sdh, succinate ..
This inhibitory quinolone is being pursued from the starting material dimethyl succinyl succinate.
metabolites are the first step for succinate synthesis.
Anderson, P.H. & Jensen, N.J. (1984) Mutagenic investigation of flavourings: Dimethyl succinate, ethyl pyruvate and aconitic acid are negative in the /mammalian-microsome test., 1, 283–288.
This study presents chemical synthesis, structural, and physical characterization of novel biodegradable aliphatic poly(butylene succinate--cyclic carbonate)s P(BS--CC) bearing functionalizable carbonate building blocks. First, five kinds of six-membered cyclic carbonate monomers, namely, trimethylene carbonate (TMC), 1-methyl-1,3-trimethylene carbonate (MTMC), 2,2-dimethyl-1,3-trimethylene carbonate (DMTMC), 5-benzyloxytrimethylene carbonate (BTMC), and 5-ethyl-5-benzyloxymethyl trimethylene carbonate (EBTMC), were well prepared from ethyl chloroformate and corresponding diols at 0 °C in THF solution with our modified synthetic strategies. Then, a series of new P(BS--CC)s were synthesized at 210 °C through a simple combination of polycondensation and ring-opening-polymerization (ROP) of hydroxyl capped PBS macromers and the prepared carbonate monomers, and titanium tetraisopropoxide Ti(-OPr)4 was used as a more suitable catalyst of 5 candidate catalysts which could concurrently catalyze polycondensation and ROP. By means of NMR, GPC, FTIR, and thermal analytical instruments, macromolecular structures and physical properties have been characterized for these aliphatic poly(ester carbonate)s. The experimental results indicated that novel biodegradable P(BS--CC)s were successfully synthesized with number average molecular weight ranging from 24.3 to 99.6 KDa and various CC molar contents without any detectable decarboxylation and that the more bulky side group was attached to a cyclic carbonate monomer, the lower reactivity for its copolymerization would be observed. The occurrences of 13C NMR signal splitting of succinyl carbonyl attributed to the BS building blocks could be proposed due to the randomized sequences of BS and CC building blocks. FTIR characterization indicated two distinct absorption bands at 1716 and 1733∼1735 cm-1, respectively, stemming from carbonyl stretching modes for corresponding BS and CC units. With regard to their thermal properties, it is seen that the synthesized P(BS--CC)s exhibited thermal degradation temperatures 10∼20 °C higher than that of PBS. On the basis of the synthesized P(BS--BTMC)s, new aliphatic poly(butylene succinate--5-hydroxy trimethylene carbonate)s were further synthesized, bearing hydrophilic hydroxyl pendant functional groups through an optimized Pd/C catalyzed hydrogenation. These semicrystalline new biodegradable aliphatic copolymers with tunable physical properties and functionalizable carbonate building blocks might be expected as potential new biomaterials.
# Question of the day | Biochemistry for Medics – …
The most common and commercially available BFC comprise esters (-nitrophenyl, pentafluorophenyl, -hydroxysuccinimide, sulfo--hydroxysuccinimide), isothiocyanates, maleimides, hydrazides, α-haloamides for the reaction with nucleophilic functional groups (-NH2, -SH, -OH) of vector molecules and formation of amide, urea, thiourea, Schiff-base, or thioester bond . Methods have been developed for the conjugation with peptides by solid-phase peptide synthesis (SPPS) resulting in defined position and number of chelate moieties. The outcome of the conjugation in solution wherein peptides and proteins comprise several reactive sites is very often a mixture of bioconjugate molecules with various content of the chelator. Such heterogeneity may cause the interpretation ambiguity of the performance of such imaging agents. Regioselective conjugation to antibodies was achieved by enzymatic reaction with lysine and glutamine residues using bacterial and human tissue transglutaminase as catalysts .
Prospective of 68Ga-Radiopharmaceutical Development
FOOD ADDITIVES AND CONTAMINANTS - IPCS INCHEM
This prevents bacterial protein synthesis
Coenzyme Q10 - Wikipedia
Erythromycin ethylsuccinate may be bacteriostatic or ..
a larger succinate plus succinyl-CoA pool and ..
erythromycin ethylsuccinate ..
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