Protein synthesis inhibitor - Wikipedia
Synergy with Cell Wall Synthesis Inhibitors is Not Always Observed In the Clinical Setting
Macrolide antibiotics ; Protein synthesis ..
Inhibitors of protein or RNA synthesis prevented prostaglandin (PG) production in isolated skeletal muscles, brain, and spleen. Incubation of rat muscles with cycloheximide prevented the stimulation of PGE2 production induced in vitro by the Ca2+ ionophore A23187 and in vivo by injection of endotoxin. Cycloheximide also inhibited the stimulation by arachidonic acid of PGE2, PGF2 alpha, and prostacyclin. These observations suggest that the block in prostanoid production results from a loss of PG synthase activity (EC 18.104.22.168). These effects were detectable within 10 min after exposure of the muscle to cycloheximide. The degree of inhibition of PG production correlated with the degree of inhibition of protein synthesis. Other inhibitors of protein synthesis, puromycin and emetine, also prevented conversion of arachidonate into PGE2 in these tissues, but they did not inhibit purified PG synthase. Exposure of muscles to actinomycin D for 20 min also reduced PGE2 production from arachidonate by 90%. Thus, both the PG synthase and its mRNA appear to be inactivated rapidly (t1/2 less than 10 min) in muscle and other mammalian tissues. The block in PG production induced by inhibitors of protein and RNA synthesis may account for their antipyrogenic actions and certain of their other physiological effects.
It means that cats lack specific metabolic (enzymatic) pathways and cannot utilize plant proteins as efficiently as animal proteins.It is very important to remember that not all proteins are created equal.Proteins derived from animal tissues have a complete amino acid profile. (Amino acids are the building blocks of proteins. Think of them as pieces of a puzzle.) Plant-based proteins do not contain the full complement (puzzle pieces) of the critical amino acids required by an obligate carnivore. The quality and composition of a protein (are all of the puzzle pieces present?) is also referred to as its biological value.Humans and dogs can take the pieces of the puzzle in the plant protein and, from those, make the missing pieces. Cats cannot do this. This is why humans and dogs can live on a vegetarian diet but cats cannot. (Note that I do not recommend vegetarian diets for dogs.)Taurine is one of the most important nutrients present in meat but it is missing from plants. Taurine deficiency will cause blindness and heart problems in cats.The protein in dry food, which is often heavily plant-based, is not equal in quality to the protein in canned food, which is meat-based. The protein in dry food, therefore, earns a lower biological value score.Because plant proteins are cheaper than meat proteins, pet food companies will have a higher profit margin when using corn, wheat, soy, rice, etc.Veterinary nutritionists and pet food company representatives will argue that they are smart enough to know *exactly* what is missing from a plant in terms of nutrient forms and amounts – nutrients that would otherwise be in a meat-based diet. They will then claim that these missing elements are added to their diets to make it complete and balanced to sustain life in an obligate carnivore.Does anyone really think that humans are that smart?This is the kind of arrogance that has led to fatal errors in the past. Not all that long ago (1980s) cats were going blind and dying from heart problems due to this arrogance. It was discovered in the late 1980s that cats are exquisitely sensitive to taurine deficiency and our cats were paying dearly for humans straying so far from nature in order to increase the profit margin of the pet food manufacturers.There are several situations that can lead to a diet being deficient in taurine but one of them is using a diet that relies heavily on plants (grains, etc.) as its source of protein. Instead of lowering their profit margin and going back to nature by adding more meat to the diets, the pet food companies simple started supplementing their diets with synthetic taurine.This may be all well and good for this particular problem, but how do we know that we are not blindly going along unaware of other critical nutrients that are missing from a plant-based diet?Why are nutritionists so arrogant to think that we can safely stray so far from what a cat is designed by nature to eat?Also note that synthetic taurine is manufactured from a chemical reaction and all taurine (at least that I know of) comes out of China. Given that country’s horrible track record with regard to food safety, I certainly would not want to depend on taurine from China’s chemical synthesis to meet my cats’ taurine needs.With regard to the overall protein amounts contained in dry versus canned food, do not be confused by the listing of the protein percentages on the packaging. At first glance, it might appear that the dry food has a higher amount of protein than the canned food—but this is not true on a dry matter basis which considers the food minus the water. Most canned foods, when figured on a dry matter basis, have more protein than dry food. And remember, even if this was not the case, the percentage numbers do not tell the whole story.
Antibiotics × Protein Synthesis ..
The best known and studied bacterial toxin is the diphtheria toxin,produced by . Diphtheria toxin is abacterialexotoxin of the A/B prototype. It is produced as single polypeptidechainwith a molecular weight of 60,000 daltons. The function of the proteinis distinguishable into two parts: subunit A, with a m.w. of 21,000daltons,contains the enzymatic activity for inhibition of elongation factor-2involvedin host protein synthesis; subunit B, with a m.w. of 39,000 daltons, isresponsible for binding to the membrane of a susceptible host cell. TheB subunit possesses a region T (translocation) domain which insertsinto the endosome membrane thus securing the release of the enzymaticcomponent into the cytoplasm.
The ideabehind this was as follows: if Morgellons is a fungus or "fungus-like"organism, such as a protozoan, then it must have chitin, so we canblock the organism's chitin synthesis simply with chitin inhibitors.
THE INHIBITION OF PROTEIN SYNTHESIS BY ANTIBIOTICS ..
Animation of protein synthesis - Answers on HealthTap
Let's review the steps of protein synthesis.
inhibit protein synthesis.
30s_protein_synthesis_inhibitors [TUSOM | Pharmwiki]
Sites of action of antibiotics that interfere with bacterial protein synthesis
30S Protein Synthesis Inhibitors
Macrolides are antibiotics that interfere with protein synthesis in susceptible bacteria
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