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inhibit , another enzyme required for ergosterol synthesis:

(1995) Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review.

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inhibit the synthesis of in the , probably via the enzyme :

Epoxy Compounds; Ergosterol/biosynthesis; Farnesyl-Diphosphate Farnesyltransferase/metabolism; Hot Temperature; Isomerases/metabolism; Lanosterol; Mevalonic Acid/metabolism; Mutation; Oxygenases/metabolism; Phosphotransferases/metabolism; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/isolation & purification; Squalene/metabolism

ergosterol biosynthetic process

mRNA extraction, cDNA synthesis, labeling, and array hybridization to Affymetrix Yeast Genome Y2.0 arrays were performed according to the manufacturer's recommendations (Affymetrix GeneChip® Expression Analysis Technical Manual, 2005-2006 Revision 2.0). Washing and staining of arrays were performed using the GeneChip Fluidics Station 450 and scanning with the Affymetrix GeneArray Scanner (Affymetrix, Santa Clara, CA).

farnesyl diphosphate biosynthetic process, mevalonate pathway

isopentenyl diphosphate biosynthetic process, mevalonate pathway

Karst, F and Lacroute, F (1977) Ertosterol biosynthesis in Saccharomyces cerevisiae: mutants deficient in the early steps of the pathway. 154:269-77

Enriched SNP in galactose uptake pathway and ergosterol synthesis pathway. Two pathways with a significant number of SNPs, both silent (blue) and nonsynonymous (red) are included: galactose uptake pathway and ergosterol synthesis pathway. The significance of each pathway (p

ergosterol biosynthetic process

ergosterol biosynthetic process

Thermosensitive mutants, auxotrophic for ergosterol synthesis, have been isolated, analyzed genetically and their enzymatic deficiencies investigated. These mutants were classified into seven unlinked complementation groups. These groupes lack the following enzymatic activities: squalene epoxidase (erg 1), 2,3-oxidosqualene-lanosterol cyclase (erg 7), phosphomevalonic kinase (erg 8), mevalonic kinase (erg12) and squalene synthetase (erg 9, erg 10, erg 11).

farnesyl diphosphate biosynthetic process, mevalonate pathway
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  • ergosterol biosynthetic process

    ergosterol biosynthetic process

  • ergosterol biosynthetic process

    ergosterol biosynthetic process

  • ergosterol biosynthetic process

    ergosterol biosynthetic process

Order now
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