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The major urinary metabolite is 2-ethylhexanoic acid.
The outbreak of neuropathy came a few months after a change in the formulation of a solvent from one composed of n-hexane, benzene fraction, ethyl acetate and toluene to a similar mixture with less (16%) n-hexane and the addition of 11% MEK.
MEK has been reported to be a metabolic end product of natural gas (methane 88%, ethane 5%, propane 5%, isobutane 2% with traces of tert-butyl mercaptan and methyl acrylate) inhaled for 2 h by ICR mice (Tsukamoto et al., 1985a).
The metabolism of 2-ethylhexanol in rats.
In rats, administration of 1600 mg/kg bw 2-ethyl-1-hexanol by gavage (but not 800 mg/kg bw) on day 12 of gestation was associated with a statistically significant increase in the number of malformed live fetuses (malformations included hydronephrosis, tail defects and limb defects).
The results of several short-term toxicity studies suggested that 2-ethyl-1-hexanol administered orally to rats and mice at doses greater than approximately 350 mg/kg bw/day induces liver peroxisome proliferation and/or marker enzymes for peroxisome proliferation.
Toxicology of 2-ethylhexanal and 2-ethyl- hexanol.
An intermittent exposure (8 h/day) of rats to 2950/31 680 mg/m3 (1000/9000 ppm) MEK/ n-hexane mixture produced severe neuropathy, whereas similar exposure to a lower concentration, i.e.
Minimum sustained continuous exposure concentrations that induced neuropathy in these experiments were 295/1408 and 590/1056 mg/m3 (100/400 and 200/300 ppm) MEK/ n-hexane mixtures.
Metabolism and disposition of di-2- ethylhexanol adipate.
Final report on the developmental toxicity of 2-ethylhexanol (CAS No.
The major urinary metabolite of EH in the rat was shown to be 2-ethylhexanoic acid through acid extraction of urine.
2-Ethyl-1-hexanol for synthesis
Foci were reported in the forestomach of 4 male and 7 female rats dosed with 1 500 mg 2-ethyl-1-hexanol/kg bw/day.
2-ethyl hexanol | Sigma-Aldrich
The Committee concluded that the available data do not indicate that 2-ethyl-1-hexanol is genotoxic.
Search results for 2-ethyl hexanol at Sigma-Aldrich
Males (9/10) and females (6/10) receiving 1 500 mg 2-ethyl-1- hexanol/kg bw/day for 11 days had clinical signs such as ataxia and lethargy, some animals also had piloerection, and a few animals showed abdominal or lateral position and loss of consciousness; one male and four females died during the study.
Synthesis of 2-ethyl hexanol fatty acid esters in a …
The following statistically significant effects were reported, associated with administration of 1 500 mg 2-ethyl-1-hexanol/kg bw/day: 1) increased absolute liver and stomach weights in males and females; 2) increased organ-to-bw ratios for stomach and liver in males and females; 3) increased organ-to-brain weight ratios for stomach and liver in males and females; 4) foci in the forestomach of 7/10 males and 5/10 females; 5) hyperkeratosis and focal or multifocal acanthosis and inflammatory oedema in the submucosa of the forestomach of most males and females, including focal or multifocal ulceration of the mucous membrane in a few males and females; 6) hypertrophy of hepatocytes in the liver of males and females, including focal necrosis of liver cells in one male and one female; and 7) bilateral tubular giant cells in the testicular tubules of two males (BASF, 1992b).
2-ETHYL HEXANOL For Synthesis - Loba Chemie
Doses of 0, 25, 125, 250, or 500 mg 2-ethyl-1-hexanol/kg bw/day were administered by gavage to groups of 10 male and 10 female B6C3F1 mice for 3 months.
2-Ethyl-1-hexanol CAS 104-76-7 | 800990 - Merck …
Statistically significant effects observed in animals receiving 500 mg 2-ethyl-1-hexanol/kg bw/day included: a) increased stomach-to-bw ratio in males and 2) slight focal or multifocal acanthosis in the mucosa of the forestomach of 2/10 males and 1/10 female (BASF, 1992b).
2-Ethylhexanol | C8H18O | ChemSpider
188.8.131.52 Rats Doses of 0, 100, 330, 1 000, or 1 500 mg 2-ethyl-1-hexanol/kg bw/day were administered by gavage for 11 days (9 applications) to groups of 10 male and 10 female Fischer 344 rats.
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