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CA 59; 11234e Synthesis of GHB and GABA

Gaba to gbl, an almost complete write up with pics . GHB Synthesis - Drug Chemistry - Hip Forums

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gamma-Hydroxybutyric acid - Wikipedia

Synthesis of the chemical GHB was first reported in 1874 by Alexander Zaytsev, but the first major research into its use in humans was conducted in the early 1960s by Dr. Henri Laborit to use in studying the neurotransmitter GABA. It quickly found a wide range of uses due to its minimal side-effects and short duration of action, the only difficulties being the narrow therapeutic dosage range (despite an unusually high LD50) and the dangers presented by its combination with and other central nervous system depressants.

GABA production - Denver Naturopathic Clinic, Inc.

GHB has at least two distinct binding sites in the central nervous system. GHB is an agonist at the newly-characterized GHB receptor, which is excitatory, and it is a weak agonist at the GABAB receptor, which is inhibitory. GHB is a naturally-occurring substance that acts in a similar fashion to some neurotransmitters in the mammalian brain. GHB is probably synthesized from GABA in GABAergic neurons, and released when the neurons fire.

gamma-Aminobutyric acid - Wikipedia

Ghb synthesis from gaba

GHB has at least two distinct binding sites in the central nervous system. GHB is an at the newly characterized GHB receptor, which is excitatory, and it is a weak at the -B receptor, which is inhibitory. GHB is a naturally occurring substance that acts in a similar fashion to some neurotransmitters in the mammalian brain. GHB is probably synthesized from in GABAergic neurons, and released when the neurons fire.

A newer synthetic drug SCH-50911, which acts as a selective GABAB antagonist, quickly reverses GHB overdose in mice. However this treatment has yet to be tried in humans and it is unlikely that it will be researched for this purpose in humans due to the illegal nature of clinical trials of GHB, and the lack of medical indemnity coverage inherent in using an untested treatment for a life-threatening overdose.

Natural StressCare: GABA - Natural Valium, or Is It?

“GHB can also be produced normally in the brain through the synthesis of a neurotransmitter called GABA; ..

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