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Synthesis Of Glycolipids And Evaluation Of Their Nkt …

02139)Studies have been continued on the synthesis of glycolipids by the NIL 2line of hamster cells.

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Genes Required for Glycolipid Synthesis and …

Studies have been continued on the synthesis of glycolipids by the NIL 2 line of hamster cells. Several clones were isolated from this line. These clones vary in morphology, saturation density, and glycolipid composition. Contrary to expectation there was no correlation between saturation density and complexity of the glycolipid pattern. In fact, the clone with the highest saturation density was the only one to show the complete set of glycolipids found previously in NIL 2 cells.

Studies have been continued on the synthesis of glycolipids by the NIL 2 line of hamster cells.

AB - The practical synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids, which incorporate two drugs into a single molecule and can impact multiple targets simultaneously are presented. These hybrids exhibited potent in vitro anticancer activity against several human cancer cell lines. The deoxoartemisinin- glycolipid hybrids generally demonstrated better anticancer activity than either artemisinin or daumone alone and cisplatin.

Stimulation of glycolipid synthesis and exchange by …

Cells transformed by hamster sarcoma virus or polyoma virusshowed no density-dependent glycolipid synthesis.

N2 - The practical synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids, which incorporate two drugs into a single molecule and can impact multiple targets simultaneously are presented. These hybrids exhibited potent in vitro anticancer activity against several human cancer cell lines. The deoxoartemisinin- glycolipid hybrids generally demonstrated better anticancer activity than either artemisinin or daumone alone and cisplatin.

Similar oxylipin-containing DGDG have been isolated from the leaves of flax plants inoculated with phytopathogenic bacteria or damaged by freezing-thawing ().

It has been shown that the DGDG synthesis increased during flower development in , the pistils and pollinic tubes containing higher amounts of this glycolipid than other floral organs ().

Glycolipid Synthesis in Normal and Transformed …

04/03/2016 · Glycolipid synthesis in normal and virus-transformed hamster cell lines

The practical synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids, which incorporate two drugs into a single molecule and can impact multiple targets simultaneously are presented. These hybrids exhibited potent in vitro anticancer activity against several human cancer cell lines. The deoxoartemisinin- glycolipid hybrids generally demonstrated better anticancer activity than either artemisinin or daumone alone and cisplatin.

All untransformed NIL clones show an increase in the level of “higher” (more than two saccharides/ceramide) glycolipids as the cells approach confluence. In the line containing all three “higher” neutral glycolipids, all three increased as cells approached saturation density. In the line containing only hematoside, this compound increased at confluence. Cells transformed by hamster sarcoma virus or polyoma virus showed no density-dependent glycolipid synthesis.

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