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protein synthesis; neuron; translation; synapse; fragile X

Steward O and Schuman EM (2001) Protein synthesis at synaptic sites on dendrites. Annual Review of Neuroscience 24: 299–325.

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Where does protein synthesis occur? - Quora

Neurons exhibit extensive and compartmentalised arbours of axons and dendrites, which place unique demands on the timing and location of protein synthesis.

Protein synthesis begins with the transcription of DNA into messenger RNA in the nucleus

Growth cones are specialised structures that guide developing axons and dendrites to their targets. Extracellular guidance cues regulate local protein synthesis in growth cones to guide axons and dendrites to their destination.

What Is the Role of DNA in Protein Synthesis

Protein synthesis is the process by which individual cells construct proteins

Neurons are immensely complex cells whose morphology and physiology underpin our cognition. Achieving proper neuronal connections during development, as well as eliciting appropriate responses to environmental stimuli in the adult, requires precisely regulated protein synthesis. To meet these requirements, neurons have adapted regulatory mechanisms that act at every step in the process of producing functional proteins. Many of these mechanisms target messenger ribonucleic acid (mRNA)‐binding proteins and ribosomal subunits to regulate translational initiation. These mechanisms are especially concentrated at synapses, where they act to transform transient electrical signals into lasting functional modifications that are a basis for learning and memory. Misregulated synaptic protein synthesis contributes to several human cognitive changes including addiction, fragile X syndrome and autism.

In the adult brain, neurons rapidly communicate through specialised contacts called synapses. The strength of communication at a synapse can be modified as a function of its past use. These changes are mediated, in part, by the local protein synthesis at the synapse.

How does DNA contribute to protein synthesis

Translation: Making Protein Synthesis Possible

After translation, the protein passes into the channels of the rough endoplasmic reticulum (ER) for transportation. The protein is then passed from the rough ER to the Golgi apparatus inside tiny fluid-filled sacs, called vesicles. The Golgi apparatus is a system of , which are responsible for the modification, processing, and packaging of the proteins. The protein may have a carbohydrate added, to form a glycoprotein. The Golgi apparatus packages the protein in a secretory vesicle, which fuses with the cell membrane and releases the protein from the cell.

This Concept Map, created with IHMC CmapTools, has information related to: Protein synthesis, mRNA processing produces an exons-only messengerRNA, peptide chain synthesize into protein, transferRNA is a type of RNA, E-site is a part of large subunit, Translation process eventually produces protein, Transcription process produces a complementary messengerRNA, transferRNA binds to amino acid, transferRNA according to its codon, binds to A-site, chromosome the most dense package of DNA (Deoxyribonucleic Acid), ribosome is built from protein, gene is a protein-synthesis data unit in the DNA (Deoxyribonucleic Acid), anti-codon is a part of transferRNA, large subunit is a part of ribosome, messengerRNA during translation, binds to mRNA binding site, messengerRNA then undergoes Translation process, small subunit is a part of ribosome, Protein Synthesis occurs when DNA (Deoxyribonucleic Acid), transferRNA being released via E-site, P-site is the creation site of peptide chain, P-site is a part of large subunit

Now that we’ve described DNA and RNA, it’s time to take a look at the process of protein synthesis
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  • Does protein synthesis occur in the nucleus? - ScienceDirect

    Nutritional regulation of muscle protein synthesis with resistance exercise: strategies to enhance anabolism

  • Protein synthesis is the process in which cells build proteins

    It is now clear that leucine stimulates muscle protein synthesis through the protein kinase mammalian target of ..

  • Where does protein synthesis take place? | Yahoo Answers

    protein synthesis occurs in cellular structures called ribosomes , found out-side the nucleus

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Protein Synthesis -Translation and Regulation

Ribosome feedback regulation, and growth rate-dependent controls of rRNA synthesis remain to be determined despite numerous investigations. r-protein. REGULATION OF RIBOSOMAL PROTEIN SyNTHESIS. control of ribosomal synthesis can be considered in relation to three basic problems 75.

Complete Information on Mechanism of Protein Synthesis …

Protein. The substrates of protein synthesis are aminoacylated tRNAs. pared with the control of transcription and. thereafter, protein synthesis on ribosomes. Aug 7, 2017. In E. coli, most ribosomal protein r-protein synthesis is coordinated with. control mechanisms to the regulation of r-protein synthesis, we. The kinetics of synthesis of ribosomal, nonribosomal, and total protein, and of. protein synthesis is regulated by control of initiation of either transcription or.

Translation - Protein Synthesis

Martin KC, Casadio A, Zhu H et al. (1997) Synapse‐specific, long‐term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage. Cell 91(7): 927–938.

Control of ribosomal protein synthesis

Since protein is the major constituent of any cell, growth regulation is closely related to the control of ribosome synthesis. In fact, the number of ribosomes per. Protein genes suggests that ribosomal protein synthesis may be regulated in. 1980, to control for differential loading of RNA on each gel lane. Because the. Ribosomal assembly requires three or four separate ribosomal RNA rRNA molecules as well as ~50–80 ribosomal proteins r-proteins; the exact numbers.

How can the answer be improved?

Sep 5, 1988. The trmD operon of Escherichia coli encodes the ribosomal proteins S16 and L19, the tRNAm1G37methyltransferase and a 21,000 Mr protein. TRNA, and that the synthesis of ribosomal protein, like the synthesis of rRNA, is subject to the influence of the rel gene control system. In exponentially growing.

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