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"Synthesis and LSD-like ..

With that, the first synthesis - that is, artificial production - of an ergot alkaloid was accomplished.

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D-Lysergic Acid Diethylamide ..

It was renamed BLUEBIRD two years later and was termed MK-ULTRA in 1953, and finally became MK-SEARCH in 1965 until its"official termination" eight years later.) MK-ULTRA was directly responsible for the wide underground availability of LSD, phencyclidine (PCP ñ also called "angel dust"), dimethyltryptamine (DMT),dimethoxyphenylethylamine (STP) and other powerful synthetic psychoactive drugs in the 1960s.

As in the first synthesis, this involved the production of only a few centigrams of the compound.

A peculiar presentiment - the feeling that this substance could possess properties other than those established in the first investigations - induced me, five years after the first synthesis, to produce LSD-25 once again so that a sample could be given to the pharmacological department for further tests.

History of lysergic acid diethylamide - Revolvy

With this synthesis, the other alkaloids existing abundantly in ergot could now be converted to ergobasine, which was valuable in obstetrics.

"FIG. 4 shows a schematic of the mode of action of Sumatriptan (Suma) upon CGRP synthesis and secretion. SNAP: synaptosomal-associated protein(s); SNP: SNAP-interacting protein; NO: nitric oxide; CGRP: calcitonin gene-related peptide.

It seemed to have resulted from some external toxic influence; I surmised a connection with the substance I had been working with at the time, lysergic acid diethylamide tartrate.

History of lysergic acid diethylamide topic

This potent synthetic put many unsuspecting people on a three-day trip, and sent many, hysterical with anxiety, to the emergency room.

Through the purification of ergotoxine, the starting material for lysergic acid, I obtained, as already mentioned, the impression that this alkaloidal preparation was not homogeneous, but was rather a mixture of different substances.

Such stimulating properties could be expected for lysergic acid diethylamide, because it shows similarity in chemical structure to the analeptic already known at that time, namely nicotinic acid diethylamide (Coramine).

In the technique known as Curtius' Synthesis, I ultimately found a process that proved useful for combining lysergic acid with amines.
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  • Chemical Synthesis Laboratory Supply Catalogs ..

    LSD Synthesis - PixelQube™

  • must be distinguished from products of improper synthesis

    18.06.2010 · The main intention of the synthesis was to o Express yourself

  • synthesised lysergic acid diethylamide ..

    events and decisions that eventually steered my work toward the synthesis of ..

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Diethylamide Molecule - Bing images

Whereas many LSD practitioners were content to strap their patients onto a 3' x 6' cot and have them attempt to perform a battery of mathematical formulae with a head full of LSD, Hubbard believed in a comfortable couch and throw pillows. He also employed icons and symbols to send the experience into a variety of different directions: someone uptight may be asked to look at a photo of a glacier, which would soon melt into blissful relaxation; a person seeking the spiritual would be directed to a picture of Jesus, and enter into a one-on-one relationship with the Savior.

PRECURSOR MATERIAL A source of lysergic acid is required

His Investigational New Drug permit also allowed Hubbard to experiment with LSD in the USA. For the next few years, Hubbard--together with Canadian psychiatrist Abram Hoffer and Dr. Humphry Osmond--pioneered a psychedelic regimen with a recovery rate of between 60% and 70%--far above that of AA or Schick Hospital's so-called "aversion therapy." Hubbard would lift mentally-disturbed lifelong alcoholics out of psychosis with a mammoth dose of liquid LSD, letting them view their destructive habits from a completely new vantage point. "As a therapist, he was one of the best," says Stolaroff, who worked with Hubbard until 1965 at the International Federation for Advanced Study in Menlo Park, California, which he founded after leaving Ampex.

Production Of Lysergic Acid By Genetic Modification Of …

In 1938, I produced the twenty-fifth substance in this series of lysergic acid derivatives: lysergic acid diethylamide, abbreviated LSD-25 (Lyserg-saure-diathylamid) for laboratory usage.

(Hydergine) LA via other ergot: or ..

"In a preferred embodiment the ergot alkaloid is selected from the group consisting of an ergoline and an ergotamine. In a more preferred embodiment, ergoline is selected from the group consisting of ergonovine, lisuride, lysergic acid, metergoline, methysergide, nicergoline, and pergolide. In another more preferred embodiment, ergotamine is selected from the group consisting of bromocriptine, dihydroergocornine, dihydroergocristine, dihydroergocryptine, dihydroergotamine, dihydroergotoxine, and ergotamine. In a yet more preferred embodiment, ergotamine is dihydroergotamine. In a most preferred embodiment dihydroergotamine is the mesylate salt.

The Homœopathic Proving of LSD-25

"In a preferred embodiment the ergot alkaloid is selected from the group consisting of an ergoline and an ergotamine. In a more preferred embodiment, ergoline is selected from the group consisting of ergonovine, lisuride, lysergic acid, metergoline, methysergide, nicergoline, and pergolide. In another more preferred embodiment, ergotamine is selected from the group consisting of bromocriptine, dihydroergocornine, dihydroergocristine, dihydroergocryptine, dihydroergotamine, dihydroergotoxine, and ergotamine. In a yet more preferred embodiment, ergotamine is dihydroergotamine. In a most preferred embodiment dihydroergotamine is the mesylate salt.

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