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Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)aniline intermediates - Patent 2894154

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Synthesis of N -Heterocycles - Organic Chemistry Portal

We believe that our phenyl-piperazine-triazine-based α-helix mimetics, along with the facile and divergent solid-phase synthetic method, have great potential as powerful tools for discovering potent inhibitors of given α-helix-mediated PPIs.


Sushil et al (2011) synthesize 2-[4-(aryl substituted) piperazin-1-yl]-N-phenylacetamides and evaluate for the anti psychotic activity. All the 10 new arylpipeazines showed variable antipsychotic activity with compound 3h being the least effective in the induction of catalepsy. Their effect may involve interaction with 5-HT2A and D2 receptors. 33

PDF Downloads : Oriental Journal of Chemistry

Jacek sapa et al (2011 synthesized a series of novel pyrrolidin-2-one derivatives (17 compounds) with adrenolytic properties were evaluated for antiarrhythmic, electrocardiographic and antioxidant activity. Some of them displayed antiarrhythmic activity in barium chloride-induced arrhythmia and in the rat coronary artery ligation-reperfusion model, and slightly decreased the heart rate, prolonged P–Q, Q–T intervals and QRS complex. Among them, compound EP-40 (1-[2-hydroxy-3-[4-[(2-hydroxyphenyl) piperazin-1-yl] propyl] pyrrolidin-2-one showed excellent antiarrhythmic activity

Alka Bali et al (2010) synthesized a series of acetophenone based 1-(Aryloxy propyl) -4-(chloro aryl) piperazine. All the synthesized compounds were evaluated for anti psychotic activity. All the targeted compounds were subjected to preliminary pharmacological evaluation to determine their ability to antagonize Apomorphine induced mesh climbing behavior and apomorphine induced stereotype in mice. Compound a1-4 and b1 and b2 shows positive result for reversal of Apomorphine induced mesh climbing and compound a5-8 shows negative response. Apomorphine used as a standard drug.

Soai Tetrahedron Lett., 1981, 2859-2862

Biological testing of these compounds proved that these have the anticonvulsant and antidepressant activities. Mutlu Dilsiz aytmir et al (2010) also reported the synthesis and evaluation of anticonvulsant activity of 3-hydroxy-6-methyl-2-substituted 4H pyran-4-one derivatives. Among the compounds 4-(3-trifluoromethyl phenyl) piperazine -1-yl methyl group at position 2 on the pyranone ring. 26

Rangappa et al. (2006) worked on the 1-[bis(4-flurophenyl)methyl]piperazine derivatives(Fig.17) synthesis and there efficacy for acetylcholinestrase inhibition as a stimulant of central cholinergic neurotramission in Alzheimer’s disease.

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  • Molbank, an international, peer-reviewed Open Access journal.

    Design, Solid-Phase Synthesis, and Evaluation of a Phenyl-Piperazine-Triazine Scaffold as α-Helix Mimetics

  • synthesis of 2, 6-methylated piperazine

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  • Design, synthesis and pharmacological evaluation of N …

    Heterocyclic Building Blocks

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