A three-phase mechanism for PLGA biodegradation has been proposed:
FIG. 2 : SYNTHESIS OF PLGA
FIG. 4 : BIODEGRADATION OF PLGA
F.G. Mondalek, B.J. Lawrence, B.P. Kropp, B.P. Grady, K.M. Fung, S.V. Madihally, H.K. Lin, The Incorporation of Poly(lactic-co-glycolic) Acid Nanoparticles into Porcine Small Intestinal Submucosa Biomaterials, Biomaterials, 29, 1159 (2008).
Poly lactic-glycol acid (PLGA) plays vital role in pharma industry especially as encapsulation material. Considering importance of polymeric material especially PLGA. In the PubMed searched we found total 937 articles were reported in the year of 2015 (01-01-2015 to 31-12-2015).In these articles we focused on reviewing advancement of PLGA nanoparticle synthesis method, characterization and applications of PLGA mediated Nano polymer ranging from drug delivery to in vivo imaging arena. The review ends with a concluding outlook on the possibilities and future challenges presented to PLGA polymer-based nanotechnologies in healthcare.
Poly(Lactide-co-Glycolide) (PLGA) Copolymers - Lactide …
They may have controlled-release properties due to their biodegradability, pH, ions and/or temperature sensitivity. All these properties can improve the utility of anticancer drugs and reduce their toxic side effects. PLGA nanoparticles linked to targeting ligands are used to target malignant tumors with high affinity. PLGA nanoparticles also have large surface areas and functional groups for conjugating to multiple diagnostic (e.g., optical, radio isotopic, or magnetic) agents. Nanoparticle carriers have high stability in biological fluids, and are more able to avoid enzymatic metabolism than other colloidal carriers, such as liposomes or lipid vesicles 4, 18, 20.
Suitable solvents include benzyl alcohol, propylene carbonate, ethyl acetate, isopropyl acetate, methyl acetate, methyl ethyl ketone, benzyl alcohol, butyl lactate, and isovaleric acid. This method has been used for PLGA nanoparticle preparation in many studies. It should be noted that the solvent evaporation process is similar to this method, in the sense that the solvent must first diffuse out into the external aqueous dispersion medium before it can be removed from the system by evaporation 10.
Study of Thermal Degradation of PLGA, PLGA Nanospheres …
Owing to their excellent biocompatibility, the biodegradable polyester called poly (D, L-lactide-co-glycolide) (PLGA) is the most frequently used biomaterial and is already commercialized for a variety of drug delivery systems (blends, films, matrices, microspheres, nanoparticles, pellets, etc.). Polymeric nanoparticles of this polymer are used for the delivery of various drugs (antipsychotic, anesthetics, antibiotics, antiparasites, antitumorals, hormones, proteins, etc.).
Physicochemical Properties of PLGA: PLGA prepared from L-poly lactide (L-PLA) and poly glycolide (PGA) are crystalline co-polymers while those from D,L-PLA and PGA are amorphous in nature It has been found that PLGAs containing >70% glycolide are amorphous in nature. Physical properties such as the M.W. affect the mechanical strength of the polymer and its ability to be formulated as a drug delivery device. Also, these properties may control the polymer biodegradation rate and hydrolysis. Commercially available PLGA polymers are usually characterized in terms of intrinsic viscosity, which is directly related to their M.W.
Synthesis, Characterization, and Study of PLGA …
The synthesis PLA, PGA, and PLGA can be ..
PEG-PLGA - Sigma-Aldrich
Recent Advancement in PLGA Nano Polymer Synthesis …
PLGA-PEG Nanoparticle Synthesis - ResearchGate
08/01/2018 · PLGA-PEG Nanoparticle Synthesis
I plan to synthesize a PLGA-PEG drug loaded nanoparticles using ..
Formulation of functionalized PLGA polymeric nanoparticles ..
Form last decade, researchers have worked towards biocompatibility, and controlled drug release to improve methodology of treatment of diseases. With improvement in Nano-micro technology, researchers have developed dual functional implantable devices which work as drug reservoir and release machine [1-2] on other hand, diffusion based drug release systems have got special attention because of its cost effective and simple synthesis methodology. Among various biocompatible polymers, PLGA poly (lactic-co-glycolic acid) is attracted noteworthy attention due to its attractive properties:
Influence of PLGA and PLGA-PEG on the dissolution …
K. Bootdee, M. Nithitanakul, B.P. Grady, “Synthesis and Encapsulation of Magnetite Nanoparticles in PLGA: Effect of Amount of PLGA on Characteristics of Encapsulated Nanoparticles”, Polymer Bulletin, 69, 195 (2012).
Polylactic-co-Glycolic Acid (PLGA) as Biodegradable …
PLGA [poly (lactic-co-glycolic acid)] is synthesized by means of ring-opening co-polymerization of two different monomers, the cyclic dimers (1,4-dioxane-2,5-diones) of glycolic acid and lactic acid. Polymers can be synthesized as either random or block copolymers thereby imparting additional polymer properties. During polymerization, successive monomeric units (of glycolic or lactic acid) are linked together in PLGA(Figure 1) X: number of units of lactic acid; y: number of units of glycolic acid. Lactic acid: glycolic acid composition of PLGA alters properties of PLGA and its applicability by ester linkages, thus yielding linear, aliphatic polyester as a product [2-3].
PLGA-PEG Block Copolymers for Drug Formulations | …
As of now research fraternity had focused on formulating spherical PLGA nanoparticle. Considering the dire need of more controlled release, one can expects research in tuning size and shape of the PLGA nanoparticles for drug delivery applications. On other hand we can expect application of PLGA in theranostic material based therapy where PLGA or related materials linked biocompatible fluorescent material or fluorescent Nanomaterial for Imaging-Guided chemo or photo thermal combinatorial therapy. Considering the future potential application of PLGA materials, in this article we have reviewed advancement of PLGA research in the year 2015. In PubMed, we searched number of articles published form 01/01/2015 to 31/12/2015 on PLGA, and we found 937 articles. Researchers have demonstrated a patrol of applications ranging from drug delivery to in vivo imaging system, which indicates the direction of future research and its current progress .
Chemical Degradation of Peptides and Proteins in PLGA: …
Figure 2 illustrates a summary of the overall advancement of research with respect to PLGA in the year of 2015. Researchers have demonstrated a patrol of applications ranging from drug delivery to in vivo imaging system. Most of researchers have adopted an emulsion or solvent evaporation based method and synthesized material were characterized by SEM/TEM, and DLS for morphology and Polydispersity indexing; for Analytical study FTIR, MS, HPLC, and zeta potential have been used as well as UV Vis spectroscopy, micro Raman spectroscopy along with LCMS [1-17]. Research in 2015 have set the platform and challenge to find alternative methods for green synthesis of monodispersed PLGA particles.
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