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Superparamagnetic Iron Oxide Nanoparticles as MRI …

Strategies for Preparing Albumin-based Nanoparticles …

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Albumin-stabilized iron oxide nanoparticles could be used as a drug delivery vehicle for DOX []. The hybrid nanoparticle exhibited efficient tumor MRI imaging with iron oxide nanoparticle and significant tumor growth inhibition with the released DOX. Magnetic nanoparticles are useful for MRI, and they exhibit the magnetic field-driven accumulation of nanoparticles at tumors []. Albumin-stabilized Fe5C2 nanoparticles showed DOX release under NIR light irradiation or acidic condition. The combination of DOX therapy and NIR light induced PTT that inhibited synergistic tumor growth. Further application of a magnet at the tumor site improved nanoparticle accumulation at the tumor, which was monitored with the intrinsic MRI ability of Fe5C2 nanoparticles.

Food Additive: Functional use(s) - thickeners, gelling agents, stabalizers and emulsifiers
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Biosafety is the primary concern in clinical translation of nanomedicine. As an intrinsic ingredient of human blood without immunogenicity and encouraged by its successful clinical application in Abraxane, albumin has been regarded as a promising material to produce nanoparticles for bioimaging and drug delivery. The strategies for synthesizing albumin-based nanoparticles could be generally categorized into five classes: template, nanocarrier, scaffold, stabilizer and albumin-polymer conjugate. This review introduces approaches utilizing albumin in the preparation of nanoparticles and thereby provides scientists with knowledge of goal-driven design on albumin-based nanomedicine.

Synthesis of polysaccharides Communication 13

DIHYDROCODEINE synthesis with efective communication of the written concept! POLYSACCHARIDES as stabilizers for the synthesis of magnetic nanoparticles
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Hydrophilic SPIONs for biological application usually consist of an iron oxide core and a surface coating. On one hand, synthesis methods of the iron oxide core, stabilizer and reaction parameters have significant effects on the size and magnetic properties of SPIONs [, -]. On the other hand, surface coating materials, functionalization materials and surface engineering methods significantly affect ultimate size in living fluid, biocompatibility, cell internalization and duration in cells [, , , ]. Therefore, to prepare ideal SPIONs, major factors such as core synthesis, surface coating and functional materials, and surface engineering methods should be carefully considered.

On the basis of the high biocompatibility and long blood circulation half-life of albumin, many studies have been devoted to the development of albumin-stabilized nanoparticles for biomedical applications [-]. Albumin could be introduced during nanoparticle synthesis or stabilizer replacement [-].


Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional ..
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Synthesis of iron oxide in the presence of an oxidant creates several forms of iron oxides including magnetite (Fe3O4) and hematite (a-Fe2O3). Application of magnetite type iron oxide nanoparticles have been studied extensively in recent years for their potential beneficial effects. The unique magnetic properties of iron oxide nanoparticles mean decreased drug expenditure and drug administration, and improved efficacy of diagnosis, targeting, and treatment of tumors.

The biocompatibility of Fe3O4 MNPs makes them suitable for biomedical application, such as in cellular therapy, tissue repair, drug delivery, and magnetofection. Recent investigations have focused on developing methods that synthesize magnetic nanoparticles with vast potential including size, charge, stability, shape, and morphology. In general, due to aggregation behavior, colloidal stability, and cytotoxicity, surface coatings of the nanoparticles are considered critical in nano research. The biodistribution of these nanoparticles in vivo is greatly affected by their surface coating properties and the influence of an external magnetic field. In addition, a number of biocompatibility assays have been performed for polysaccharide-coated magnetic nanoparticles, due to concerns regarding the risks and benefits of magnetic nanoparticles and related technologies to human health and the environment.

magnetic nanoparticles synthesis ..
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  • and Stabilizers, Polysaccharides


  • Templated Synthesis of Magnetic Nanoparticles ..


  • Templated Synthesis of Magnetic Nanoparticles through the ..

    Sirisha, compounds (Suri et al

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polymers as steric stabilizers in solution ..

Hypoxia is regarded as a key feature of the tumor microenvironment that significantly influences tumor treatment response. An albumin-stabilized gold nanoparticle was synthesized for tumor hypoxia imaging (Figure a) []. The nanoparticle was modified with hypoxia-sensitive nitroimidazole moiety, which was converted into amine groups in the presence of nitroreductase. Conversion from the nitro group of nitroimidazole to the amino group helped increase the zeta potential of the prepared nanoparticle, which thereby improved cell internalization for accumulation at the tumor . The designed nanoparticle displayed enhanced X-CT imaging for tumor hypoxia

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