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Prostaglandin E1 (PGE1), also known as alprostadil, ..

Prostaglandin E1 - Wikipedia

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Prostaglandin H2 Synthase-1 - Kenyon College

Prostaglandin E2 (PGE2) is generated fromthe action of onprostaglandin H2 (PGH2). Severalprostaglandin E synthases have been identified. To date, microsomalprostaglandin E synthase-1 emerges as a key enzyme in the formationof PGE2.

01/10/2001 · Lipopolysaccharide-induced increase of prostaglandin E(2) ..

COX-2 plays an important role in the basal production of prostacylin (PGI2) in the vascular endothelium. COX-2 also serves an important role for normal renal development and maintenance of renal physiology. COX-2 expression can also be upregulated by cytokines, and is a major source of prostanoids produced during inflammation and cancer (Smyth & FitzGerald, 2012).

It also inhibits prostaglandin biosynthesis.

When NSAIDs inhibit COX-1 mediated prostaglandin production, ..

Figure 2. The cyclooxygenase cascade. Arachidonic acid is converted by COX-1 or COX-2 to an unstable intermediate prostaglandin H2 which is converted to different biologically active prostanoids depending on the presence of different tissue-specific isomerases. Some of the tissues in which prostanoids exert their most significant effects are listed. Modified from Fitzgeral (2003). Low dose aspirin has a selective effect to irreversibly inhibit COX-1 (at higher doses, aspirin also irreversibly inhibits COX-2). Most non-aspirin NSAIDs are relatively non-selective & reversibly inhibit both COX-1 & COX-2. Coxibs are a subclass of NSAIDs that selectively & reversibly inhibit COX-2.

In 1971, it was determined that -like drugs could inhibit the synthesisof prostaglandins. The , and jointly received the 1982 for their research onprostaglandins.

Prostaglandin | Wiki | Everipedia

1. A plant pigment that is the basis of the flavonoids; it is a potent inhibitor of prostaglandin biosynthesis.

Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1 Molecular
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