Prostaglandin E1 (PGE1), also known as alprostadil, ..
Prostaglandin E1 - Wikipedia
Prostaglandin H2 Synthase-1 - Kenyon College
Prostaglandin E2 (PGE2) is generated fromthe action of onprostaglandin H2 (PGH2). Severalprostaglandin E synthases have been identified. To date, microsomalprostaglandin E synthase-1 emerges as a key enzyme in the formationof PGE2.
COX-2 plays an important role in the basal production of prostacylin (PGI2) in the vascular endothelium. COX-2 also serves an important role for normal renal development and maintenance of renal physiology. COX-2 expression can also be upregulated by cytokines, and is a major source of prostanoids produced during inflammation and cancer (Smyth & FitzGerald, 2012).
It also inhibits prostaglandin biosynthesis.
Figure 2. The cyclooxygenase cascade. Arachidonic acid is converted by COX-1 or COX-2 to an unstable intermediate prostaglandin H2 which is converted to different biologically active prostanoids depending on the presence of different tissue-specific isomerases. Some of the tissues in which prostanoids exert their most significant effects are listed. Modified from Fitzgeral (2003). Low dose aspirin has a selective effect to irreversibly inhibit COX-1 (at higher doses, aspirin also irreversibly inhibits COX-2). Most non-aspirin NSAIDs are relatively non-selective & reversibly inhibit both COX-1 & COX-2. Coxibs are a subclass of NSAIDs that selectively & reversibly inhibit COX-2.
In 1971, it was determined that -like drugs could inhibit the synthesisof prostaglandins. The , and jointly received the 1982 for their research onprostaglandins.
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Prostaglandin 2 biosynthesis and metabolism FM
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Every prostaglandin contains 20 carbon atoms, ..
Prostaglandin E1 - Revolvy
Prostaglandins | Prostaglandin | Lipid
Prostaglandin - Wikipedia
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