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Prostaglandin E2 as a mediator of fever: synthesis …

Prostaglandin E2 as a mediator of fever: ..

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as a mediator of fever: synthesis and catabolism.

COX-2 plays a key role in the pathogenesis of inflammation, for its expression is markedly upregulated by inflammatory stimuli leading to increased synthesis of prostanoids (potent lipid inflammatory mediators) in inflamed tissues. Prostaglandin E2 (PGE2) is the most abundant prostanoid detected in inflamed tissues and its effect is mediated through activation of the EP receptors located in the plasma membrane (EP1, EP2, EP3, and EP4), which belong to the G protein-coupled receptor (GPCR) superfamily of seven-transmembrane spanning proteins(-). In fact, the conventional view that LPS-induced fever is mediated by pyrogenic cytokines is being gradually replaced by the concept that it is initiated by the production of PGE2(, ).

Prostaglandin E2 as a mediator of fever…

During illnesses caused by infectious disease or other sources of inflammation, a suite of brain-mediated responses called the “sickness syndrome” occurs, including fever, anorexia, sleepiness, hyperalgesia, and elevated corticosteroid secretion. Much of the sickness syndrome is mediated by prostaglandins acting on the brain, and can be prevented by non-steroidal anti-inflammatory drugs, such as aspirin or ibuprofen, that block prostaglandin synthesis. By examining which prostaglandins are produced at which sites and how they interact with the nervous system, researchers have identified specific neural circuits that underlie the sickness syndrome.

Prostaglandin E2 as a mediator of fever: Synthesis and catabolism

Prostaglandin E2 as a mediator of fever: synthesis and catabolism

Endothelial cells of the rat brain vasculature express cyclooxygenase‐2 mRNA in response to systemic interleukin‐1 beta: A possible site of prostaglandin synthesis responsible for fever.

Prostaglandin E2 as a mediator of fever: synthesis and catabolism

2 as a mediator of fever: synthesis and catabolism ..

as a mediator of fever: Synthesis and catabolism.

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  • Prostaglandin E 2 as a mediator of fever: synthesis and catabolism.

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