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Maximal Protein Synthesis & Resistance Trained Athletes!

“Haematopoietic stem cells require a highly regulated protein synthesis rate.” Nature 509 (7498): 49-54.

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Protein Synthesis Rate Assessment by Fluorescence …

AB - Testosterone (T) administration is known to increase muscle anabolism. However, traditional injections may not be maximally effective in the burned patient due to increased lipogenesis and lipid storage. Therefore, the effects of T infusion on skeletal muscle protein synthesis were investigated in normal male volunteers. Three subjects received 30 mg of methyl-testosterone infusion or the carrier (Intralipid) over a five hour period. Subjects were studied in a randomized manner and were blinded to the treatment. Muscle biopsies of the vastus lateralis were taken at 2 and 5 h of infusion. Fractional synthetic rate (FSR) was calculated based on the precursor-product method. The average intracellular enrichment over the time of incorporation was used as the precursor, whereas the change in protein-bound enrichment of ring-d, -phenylalanine from 2 to 5 h of infusion was the product. There was a trend toward increased FSR during T infusion (0.0801 0.018 (SD) vs 0.048 ±0.018 %/hr). However, this increase railed to reach statistical significance by paired t-test (p = 0.10). Contrary to our previous finding with chronic T injections, acute administration of T may not be a potent stimulator of muscle protein synthesis.

For example, there are almost no data on protein synthesis in any somatic stem cell.

Gluconeogenesis also is increased, and hepatic extraction of alanine, a key amino acid gluconeogenic precursor, is accelerated.19 Excessive rates of hepatic glucose production, proteolysis, and amino acid oxidation in type 1 diabetes are all reduced by insulin administration,82 but proteolysis and amino acid oxidation are more resistant to the suppressive effects of insulin.83 Normalization of protein metabolic rates may, therefore, require long-term tight metabolic control.84 Today, with improved glycemic management in type 1 diabetes, a more normal protein synthesis, breakdown, and oxidation should occur.

The Ultimate Guide to Muscle Protein Synthesis

Pten deletion increased protein synthesis in HSCs but also reduced HSC function.

AB - Although androgenic and estrogenic steroids are widely used to enhance muscle growth and increase feed efficiency in feedlot cattle, their mechanism of action is not well understood. Although in vivo studies have indicated that androgens affect protein synthesis and protein degradation rate in muscle, results from in vitro studies have been inconsistent. We have examined the effects of trenbolone acetate (TBA), a synthetic androgen, on protein synthesis and degradation rates in fused bovine satellite cell (BSC) cultures. Additionally, we have examined the effects of compounds that interfere with binding of TBA or insulin-like growth factor-1 (IGF-1) to their respective receptors on TBA-induced alterations in protein synthesis and degradation rates in BSC cultures. Treatment of fused BSC cultures with TBA results in a concentration-dependent increase (P

Rpl24Bst/+ cell-autonomously rescued the effects of Pten deletion in HSCs, blocking the increase in protein synthesis, restoring HSC function, and delaying leukaemogenesis.

7 Answers - What is protein synthesis? - Quora

N2 - Testosterone (T) administration is known to increase muscle anabolism. However, traditional injections may not be maximally effective in the burned patient due to increased lipogenesis and lipid storage. Therefore, the effects of T infusion on skeletal muscle protein synthesis were investigated in normal male volunteers. Three subjects received 30 mg of methyl-testosterone infusion or the carrier (Intralipid) over a five hour period. Subjects were studied in a randomized manner and were blinded to the treatment. Muscle biopsies of the vastus lateralis were taken at 2 and 5 h of infusion. Fractional synthetic rate (FSR) was calculated based on the precursor-product method. The average intracellular enrichment over the time of incorporation was used as the precursor, whereas the change in protein-bound enrichment of ring-d, -phenylalanine from 2 to 5 h of infusion was the product. There was a trend toward increased FSR during T infusion (0.0801 0.018 (SD) vs 0.048 ±0.018 %/hr). However, this increase railed to reach statistical significance by paired t-test (p = 0.10). Contrary to our previous finding with chronic T injections, acute administration of T may not be a potent stimulator of muscle protein synthesis.

N2 - Although androgenic and estrogenic steroids are widely used to enhance muscle growth and increase feed efficiency in feedlot cattle, their mechanism of action is not well understood. Although in vivo studies have indicated that androgens affect protein synthesis and protein degradation rate in muscle, results from in vitro studies have been inconsistent. We have examined the effects of trenbolone acetate (TBA), a synthetic androgen, on protein synthesis and degradation rates in fused bovine satellite cell (BSC) cultures. Additionally, we have examined the effects of compounds that interfere with binding of TBA or insulin-like growth factor-1 (IGF-1) to their respective receptors on TBA-induced alterations in protein synthesis and degradation rates in BSC cultures. Treatment of fused BSC cultures with TBA results in a concentration-dependent increase (P

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  • which is then used as a template for protein synthesis by the ..

    Reduced ribosome function in Rpl24Bst/+ mice further reduced protein synthesis in HSCs and impaired HSC function.

  • where protein synthesis then takes place

    T1 - Fractional synthetic rate of skeletal muscle protein during testosterone infusion

  • Ribosomes - Protein Synthesis - Museum of the Future

    Pten deficiency thus depletes HSCs and promotes leukaemia partly by increasing protein synthesis.

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Research Review: Fast vs. slow whey for protein synthesis

Testosterone (T) administration is known to increase muscle anabolism. However, traditional injections may not be maximally effective in the burned patient due to increased lipogenesis and lipid storage. Therefore, the effects of T infusion on skeletal muscle protein synthesis were investigated in normal male volunteers. Three subjects received 30 mg of methyl-testosterone infusion or the carrier (Intralipid) over a five hour period. Subjects were studied in a randomized manner and were blinded to the treatment. Muscle biopsies of the vastus lateralis were taken at 2 and 5 h of infusion. Fractional synthetic rate (FSR) was calculated based on the precursor-product method. The average intracellular enrichment over the time of incorporation was used as the precursor, whereas the change in protein-bound enrichment of ring-d, -phenylalanine from 2 to 5 h of infusion was the product. There was a trend toward increased FSR during T infusion (0.0801 0.018 (SD) vs 0.048 ±0.018 %/hr). However, this increase railed to reach statistical significance by paired t-test (p = 0.10). Contrary to our previous finding with chronic T injections, acute administration of T may not be a potent stimulator of muscle protein synthesis.

07/04/2015 · What is protein synthesis

We found that the amount of protein synthesized per hour in haematopoietic stem cells (HSCs) in vivo was lower than in most other haematopoietic cells, even if we controlled for differences in cell cycle status or forced HSCs to undergo self-renewing divisions.

protein synthesis, muscle growth, recovery, leucine, whey ..

T1 - A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly

Protein Synthesis -Translation and Regulation

Protein synthesis rate (PSR) can be assessed in vivo using positron emission tomography with L-[1-11C]tyrosine (TYR-PET). Biological activity of soft tissue sarcomas (STS) can be measured in vitro by the mitotic rate and number of proliferating cells. In STS the grade of malignancy, in which the mitotic index plays a major role, is considered to be the major standard in predicting biological tumour behaviour. This study was designed to test the validity of TYR-PET in relation to different histopathological features. In 21 patients with untreated STS, the PSR was measured using TYR-PET. The number of mitoses was counted and tumours were graded according to the grading system of Coindre et al. (Cancer 1986; 58:306-309). Proliferative activity was assessed by immunohistological detection of the Ki-67 nuclear antigen using MIB-1 monoclonal antibody. To test the association between the PSR and these tumour parameters, a correlation analysis was performed. A significant (P

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