Burdock, G.A. & Ford, R.A. (1990) Acute oral toxicity (LD50) study in the rat with 2-(mercaptomethyl)pyrazine. ., 1, 4.
What are the mechanism of reaction in preparing pyrazine?
There are often challenges in synthetic chemistry or radiochemistry to obtain the desired probe once the biochemical and physiological characteristics are optimized. Depending on the imaging modality, the synthetic chemistry requirements may vary considerably. For example, optical probes are challenged to maximize photon yield while minimizing photobleaching. PET probes are challenged by their shorter half-life and dependence on automation to reduce radiation exposure. For a PET imaging agent to succeed, a reliable and efficient method of synthesis that is translatable across radiochemistry facilities must be established. Furthermore, the synthesis method must be amenable to current Good Manufacturing Practice (cGMP) methods with a comprehensive quality assurance program if the probe is to be applied in human subjects.
Alkyl-substituted pyrazines may undergo ring hydroxylation as an alternative pathway when other routes of detoxication are less favourable. For example, 2,5- and 2,6-dimethylpyrazine (Nos 766 and 767) are oxidized in rats almost exclusively their aliphatic side-chains to carboxylic acid derivatives. Conversely, 2,3-dimethylpyrazine (No. 765) undergoes primarily ring hydroxylation, because side-chain oxidation is impaired (only 13% of the administered dose is oxidized) by the steric hindrance of the methyl groups (Hawksworth & Scheline, 1975).
the organic synthesis of pyrazine and its ..
Yamada, K., Shimizu, A., Komatsu, H., Sakata, R. & Ohta, A. (1994) Effects of 2,5-dimethylpyrazine on plasma testosterone and polyamines and acid phosphatase-levels in the rat prostate. ., 17, 730–731.
Yamada, K., Shimizu, A. & Ohta, A. (1993) Effects of dimethylpyrazine isomers on reproductive and accessory reproductive organs in male rats. .,16, 203–206.
Synthesis of imidazo[1,2-a]pyrazine and ..
Yamada, K., Takahashi, H. & Ohta, A. (1992) Effects of 2,5-dimethylpyrazine on reproductive and accessory reproductive organs in female rats. ., 75, 99–107.
Wallin, H., Holme, J.A., Becher, G. & Alexander, J. (1989) Metabolism of the food carcinogen 2-amino-3,8-dimethylimidazo[4,5-ƒ]quinoxaline in isolated rat liver cells. ,10, 1277–1283.
Pyridine synthesis - Organic chemistry
The Chemistry of Pyrazine and Its Derivatives
Pyrimidine is a fragrant heterocyclic natural compound like pyridine.:250 alternate diazines are pyrazine ..
Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy …
Pyrazine - Wikipedia
HSN codes for organic chemicals - HOW to Export …
Pyrimidine - Wikipedia
Oxadiazoles - Heterocyclic Building Blocks | Sigma-Aldrich
Turesky, R.J., Aeschbacher, H.U., Würzner, H.P., Skipper, P.L. & Tannenbaum, R.S. (1988) Major routes of metabolism of the food-borne carcinogen 2-amino-3,8-dimethyl-imidazo[4,5-]quinoxaline in the rat. , 9, 1043–1048.
Deubiquitinase inhibition as a cancer therapeutic …
The regulatory aspect tetrahydrobiopterin biosynthesis is complex, and a universal regulatory scheme for all pterins in all tissues does not exist. Expression of GTPCH is inducible. The rate limiting step for the synthesis of tetrahydrobiopterin is the hydrolysis by GTPCH . The cellular concentration of tetrahydrobiopterin is regulated by GTPCH-I. The activity of GTPCH can be regulated at the transcriptional and post translation levels. Various cytokines, phytohaemagglutinin, endotoxin and hormones induce the GTPCH gene resulting in a higher level of tetrahydrobiopterin. At the post transcriptional level GTPCH is also regulated through the cleavage of N-terminal amino acid and phosphorylation. The higher the phosphorylation level, the higher the enzymatic activity, which results in an increased amount of cellular tetrahydrobiopterin. It appears that the one of the serine residues in the GTPCH is modified by the casein kinase II and/or protein kinase C .
PYRAZINE DERIVATIVES (JECFA Food Additives Series 48)
Sjödin, P., Wallin, H., Alexander, J. & Jägerstad, M. (1989) Disposition and metabolism of the food mutagen 2-amino-3,8-dimethylimidazo[4,5-]quinoxaline (MeIQx) in rats. , 10, 1269–1275.
2-methoxy-4-vinyl phenol, 7786-61-0 - The Good …
In March 2015, NASA Ames researchers revealed that, out of the blue, complex DNA and RNA natural mixes of life, including uracil, cytosine and thymine, have been framed in the lab under space conditions, utilizing beginning chemicals, for example, pyrimidine, found in shooting stars. Pyrimidine, as polycyclic sweet-smelling hydrocarbons (PAHs), the most carbon-rich synthetic found in the universe, may have been shaped in red monsters or in interstellar clean and gas mists.
2,6-xylenol, 576-26-1 - The Good Scents Company
20. Peat AJ, Boucheron JA, Dickerson SH, Garrido D, Mills W, Peckham J. . Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors. 2004;14:2121-25
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