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Regulation of secondary biosynthesis in Gibberella fujikuroi

Lange MJP and Lange T (2006) Gibberellin biosynthesis and the regulation of plant development. Plant Biology 8(3): 281–290.

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Regulation of Gibberellin Biosynthesis in Gibberella fujikuroi.

Fusarium verticillioides (Gibberella fujikuroi mating population A [MP-A]) is a widespread pathogen on maize and is well-known for producing fumonisins, mycotoxins that cause severe disease in animals and humans. The species is a member of the Gibberella fujikuroi species complex, which consists of at least 11 different biological species, termed MP-A to -K. All members of this species complex are known to produce a variety of secondary metabolites. The production of gibberellins (GAs), a group of diterpenoid plant hormones, is mainly restricted to Fusarium fujikuroi (G. fujikuroi MP-C) and Fusarium konzum (MP-I), although most members of the G. fujikuroi species complex contain the GA biosynthesis gene cluster or parts of it. In this work, we show that the inability to produce GAs in F. verticillioides (MP-A) is due to the loss of a majority of the GA gene cluster as found in F. fujikuroi. The remaining part of the cluster consists of the full-length F. verticillioides des gene (Fvdes), encoding the GA4 desaturase, and the coding region of FvP450-4, encoding the ent-kaurene oxidase. Both genes share a high degree of sequence identity with the corresponding genes of F. fujikuroi. The GA production capacity of F. verticillioides was restored by transforming a cosmid with the entire GA gene cluster from F. fujikuroi, indicating the existence of an active regulation system in F. verticillioides. Furthermore, the GA4 desaturase gene des from F. verticillioides encodes an active enzyme which was able to restore the GA production in a corresponding des deletion mutant of F. fujikuroi.

Biosynthesis of gibberellins in Gibberella fujikuroi: biomolecular aspects.

Hedden P, Phillips AL, Rojas MC, Carrera E and Tudzynski B (2002) Gibberellin biosynthesis in plants and fungi: a case of convergent evolution? Journal of Plant Growth Regulation 20(4): 319–331.

Regulation of Gibberellin Biosynthesis in Gibberella fujikuroi

Gibberellin biosynthesis in Gibberella fujikuroi: cloning and characterization of the copalyl diphosphate synthase gene.

Hedden P and Croker SJ (1992) Regulation of gibberellin biosynthesis in maize seedlings. In: Karssen CM, Van Loon LC and Vreugdenhil D (eds) Progress in Plant Growth Regulation: Proceedings of the 14th International Conference on Plant Growth Substances, pp. 534–544. Dordrecht: Kluwer.

Rojas MC, Hedden P, Gaskin P and Tudzynski B (2001) The P450‐1 gene of Gibberella fujikuroi encodes a multifunctional enzyme in gibberellin biosynthesis. Proceedings of the National Academy of Sciences of the USA 98(10): 5838–5843.

Gibberellin biosynthesis and the regulation of plant ..

A polyketide synthase gene required for biosynthesis of fumonisin mycotoxins in Gibberella fujikuroi mating population A.

The concentration of the biologically active gibberellins is tightly regulated in most plant tissues at the level of biosynthesis and deactivation.

Silverstone AL, Chang CW, Krol E and Sun TP (1997) Developmental regulation of the gibberellin biosynthetic gene GA1 in Arabidopsis thaliana. Plant Journal 12(1): 9–19.

1992 Regulation of Gibberellin Biosynthesis in Gibberella fujikuroi' Reyes Candau2, ..
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    New bioregulators of gibberellin biosynthesis in Gibberella fujikuroi.

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Gibberella fujikuroi | Plant Hormone | Fruit - Scribd

Fusarium verticillioides (Sacc.) Nirenberg (synonym Fusarium moniliforme; teleomorph Gibberella fujikuroi MP-A or Gibberella moniliformis) is a widespread pathogen of maize plants causing ear and stalk rot disease (, ) and belongs to the Gibberella fujikuroi (Sawada) species complex. This complex includes important fungal pathogens of a variety of crops, such as maize, rice, barley, sugarcane, pine, mango, pineapple, and sorghum (). It comprises 11 sexually fertile biological species, also known as mating populations (MPs; MP-A to -K), and more than 30 anamorphic species (genus Fusarium, sections Liseola, Elegans, and Dlaminia) (, , , , ). Members of the species complex produce a broad variety of mycotoxins and other secondary metabolites, such as moniliformin (), fusaric acid (), beauvericin (), gibberellins (GAs) (), bikaverin (), and fumonisins (, , , ).

Gibberellin production by Gibberella ..

It is noteworthy that some secondary metabolites are produced by more than one species in the complex, whereas other metabolites are produced only by one species. Thus, fumonisins are produced by F. proliferatum and F. fujikuroi, as well as by F. verticillioides (, , , ), moniliformin by F. verticillioides, F. fujikuroi and F. thapsinum (, ), and beauvericin by isolates of F. fujikuroi, F. proliferatum, and F. subglutinans (, ). In contrast, the production of GAs, a group of plant hormones, is so far mainly restricted to F. fujikuroi (MP-C) and F. konzum (MP-I), although several species of the G. fujikuroi species complex contain the entire GA-biosynthetic gene cluster (, , ).

Pharmaceutical & Medicinal Chemistry

The genetics and biochemistry of GA production in the rice pathogen F. fujikuroi have been well characterized in recent years (, , , ). The GA biosynthesis genes in F. fujikuroi are organized in a gene cluster (, ), as is often the case for secondary-metabolite biosynthesis pathways in fungi, e.g., the genes for the biosynthesis of fumonisins in F. verticillioides (), aurofusarin in Fusarium graminearum (), and aflatoxin and sterigmatocystin in Aspergillus species ().

28/09/2007 · How to Cite

In Aspergillus spp., the velvet gene (veA) regulates the biosynthesis of several secondary metabolites, including the polyketide toxins sterigmatocystin and aflatoxin (-). Whether veA homologs have a similar role in regulation of toxin production in other fungal genera has not been investigated. Previously, we identified FvVE1, a veA homolog in F. verticillioides, and demonstrated that it functions in regulation of morphogenesis (). In this study, we investigate the role of FvVE1 in secondary metabolism in F. verticillioides, specifically in the biosynthesis of fumonisin and fusarins. Our results suggest that FvVE1 regulates biosynthesis of both fumonisin and fusarins in this important plant pathogenic fungus.

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