Reverse micelle synthesis of rhodium ..
Reverse Micelle Synthesis and Characterization of Superparamagnetic MnFe2O4 Spinel Ferrite Nanocrystallites
Reverse micelle synthesis of perovskite oxide nanoparticles
The role of nanoparticle geometry in tumor targeting has received relatively little attention, although it is important for determining the binding affinity for a target cell. Sailor . systemically optimized tumor targeting by varying the nanomaterial shape (elongated versus spherical), targeting ligand type (cell surface targeting versus extracellular matrix targeting), ligand surface coverage, and attachment chemistry (Figure ) . They prepared two types of tumor-targeting peptides (F3 or CREKA) and conjugated the peptides to magnetic nanoworms (NWs) or magnetic nanospheres (NSs) at varying numbers of targeting peptides and for varying PEG lengths. Intravenous injection of the magnetic nanostructures in the tumor xenograft mice models revealed that the tumor-targeting properties of the NWs were superior to those of the NSs due to multivalent interactions between the elongated NWs and the receptors on the tumor cell surfaces. The smaller neutral CREKA targeting moiety was more effective than the larger positively charged F3 targeting moiety, presumably because multiple copies of the highly cationic F3 caused a large increase in the surface charge on the particles, which facilitated clearance by the MPS-related organs. The most effective number of CREKA peptides was 60 per NW. Above 60 peptides per NW, the blood circulation time decreased. For a given number of peptides bound to the NWs, the presence of a PEG linker facilitated peptide targeting by reducing conformational restriction as well as increasing the residence time of the nanostructures in the blood stream. The short SMCC linker restricted the targeting peptide conformation. These results suggest some design guidelines for the development of targeted multifunctional nanoparticle systems for cancer imaging and therapy.
(A) Schematic representation and TEM image of RGD-Dox-NP (scale bar indicates 100 nm). (B) Vascular disruption in the mouse Matrigel model with intravenous injection of PBS or αvβ3-targeted RGD-Dox-NPs on days 1, 3, and 5. After treatment, mice were intravenously injected with fluorescein-labeled lectin, and the plugs were removed and imaged by scanning confocal microscopy. (C) Suppression of metastasis in an orthotopic model of pancreatic cancer. After surgical implantation of the cells, mice were treated on days 5, 7, and 9 with RGD-Dox-NPs, RAD-Dox-NPs, free Dox, or PBS (each with 1 mg/kg total Dox per dose). On day 11, the primary tumor and the hepatic hilar lymph node were resected and weighed. Reproduced with permission from ref. .
01/02/2013 · Reverse micelle synthesis of silver ..
25. Hong RL, Huang CJ, Tseng YL, Pang VF, Chen ST, Liu JJ. . Direct comparison of liposomal doxorubicin with or without polyethylene glycol coating in C-26 tumor-bearing mice: Is surface coating with polyethylene glycol beneficial. 1999;5:3645-52
It has become increasingly clear that the tumor-targeting properties of the nanoparticles optimized are not predictive of the performance. Farokhzad and Langer identified maximally targeted and maximally stealth surface engineering conditions for and performance using PSMA targeted aptamer-conjugated Dtxl-loaded self-assembled nanoparticles . Nanoparticles were prepared with different compositions of the self-assembled diblock copolymers and aptamers, and the optimal aptamer density on the nanoparticle surface was initially determined . Increasing the ligand density to 5% significantly increased the nanoparticle uptake by the target cells (LNCaP), whereas further increase in aptamer density modestly increased the nanoparticle uptake. These results indicated that the optimum ligand density for PSMA-specific endocytosis was 10-80 nmol aptamer per μmol nanoparticle. LNCaP xenograft mouse models injected with the targeted nanoparticles showed that increasing the aptamer density from 0% to 5% significantly increased nanoparticle retention in tumors, but the retention decreased for aptamer densities beyond 10%. The authors suggested that higher aptamer densities may have reduced the nanoparticle stealth properties, resulting in rapid clearance by the liver. Gabizon . optimized the ligand density in the Her2-targeted PEGylated liposomal Dox system (HT-PLD) for ligand ratios of 7.5, 15, or 30 per liposome . The best safety margin and performance resulted from a ligand density of 15 ligands per liposome in the HT-PLD formulation. A 30 ligand ratio accelerated plasma clearance in the tumor-bearing mice, and the 7.5 ligand ratio reduced cytotoxicity after passage.
Reverse micellar synthesis of cerium ..
Lee decorated liposomal Dox with a lung tumor targeted peptide . Lung cancer is the leading cause of death due to cancer, and its high mortality rate appears to derive from a low therapeutic index for chemotherapy and late detection due to a lack of sensitive diagnostic biomarkers . The identification of novel biomarkers for early lung cancer detection remains a challenge. In this study, a novel peptide (CSNIDARAC) with a high binding affinity for lung tumors was identified by screening of a phage display peptide library, and CSNIDARAC peptide-conjugated liposomal Dox (Lipo-Dox) was synthesized. The tumor targeting capabilities and the therapeutic efficacy were evaluated in the H460 tumor xenograft mice. To minimize the interactions between the targeted peptide and the surface of the liposome, the amount of PEG on the surface of the liposome was reduced from 5-20 mol% (general use) to 1.3 mol% of total lipids. Tumor growth inhibition of the peptide-targeted Lipo-Dox was superior to that of the untargeted Lipo-Dox or free Dox administered at an equivalent dose, and this result was consistent with the levels of apoptosis measured by TUNEL staining. Near-IR Cy7.5 dye-labeled peptide-conjugated Lipo-Dox also showed a distinct fluorescence signal at the tumor, whereas untargeted Lipo-Dox did not show such a strong signal intensity, suggesting the potential utility of this lung tumor-targeting peptide as a diagnostic agent.
(A) Schematic diagram of the NPCP-Cy5.5-CTX nanoprobes. MR images of ND2:SmoA1 (B) and wild-type mice (C) acquired before and 48 h after administration of either NPCP-CTX or the NPCP nanoprobes. Colorized R2 maps of the brain region were superimposed onto the proton density-weighted images. (D-E) near-IR fluorescence images of autochthonous medulloblastoma tumors in ND2:SmoA1 mice injected with NPCP-Cy5.5-CTX or NPCP-Cy5.5, alongside those receiving no injection: 2 h post-injection (D) and 120 h post-injection (E). fluorescence images of mice brains from the same mice following necropsy (inset). The spectral gradient bar corresponds to the fluorescence intensity (p/s/cm2/sr) in the images. Reproduced with permission from ref. .
Nanoparticle Synthesis Using Reverse Micelle ..
Metallic Nanoparticle Synthesis within Reverse ..
14/04/2010 · Synthesis and size control of silver nanoparticles using reverse micelles of ..
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(17f) Reverse Micelle Synthesis and Characterization of Nanoparticle Catalysts for Tri Reforming of CO2
The polarization resistance of the nanoparticle ..
20/12/2004 · Synthesis of Platinum/Silica Nanocomposite Particles by Reverse Micelle ..
International Journal of Nanomedicine - Dove Press
(A) Schematic representation of nanoparticle communication to achieve amplified tumor targeting. Tumor-targeted signaling nanoparticles (blue) broadcast the tumor location to the receiving nanoparticles (red) present in circulation. (B) Shown are the harnessing of the biological cascade to transmit and amplify nanoparticle communication and the molecular signaling pathway between the signaling and receiving components. (C) Thermographic images of the photothermal NRs with heating. Seventy-two hours after NR or saline injection, mice were co-injected with FXIII-NWs and untargeted control-NWs, and their right flanks were broadly irradiated (top). Twenty-four hours post-irradiation, whole-animal fluorescence imaging revealed the distribution of the receiving nanoparticles (bottom). (D) Amplified tumor therapy with communicating nanoparticles. Tumor volumes following a single treatment with the communicating nanoparticle systems and controls. Reproduced with permission from ref. .
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(A) Schematic diagram showing the synthesis of MN-EPPT-siBIRC5. (B) Representative pre-contrast images and 24 h post-contrast T2-weighted images (top), and color-coded T2 maps (bottom) of the tumor-bearing mice intravenously injected with MN-EPPT-siBIRC5 (10 mg/kg Fe). (C) Relative tumor volume measurements of MN-EPPT-siBIRC5- and MN-EPPT-siSCR-injected animals over the course of treatment. Reproduced with permission from ref. .
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(A) Schematic diagram showing bioconjugation of HAuNS-siRNA and photothermal-induced siRNA release. (B) Schematic diagram showing the synthesis of F-PEG-HAuNS-siRNA and the proposed intracellular events following near-IR irradiation. (C) Effect of p65 siRNA photothermal transfection combined with irinotecan delivered to nude mice bearing HeLa cancer xenografts. (D) Micro-PET/CT imaging of nude mice bearing HeLa cervical cancer xenografts in right rear leg 6 h after intravenous injection of F-PEG-HAuNS-siRNA(DOTA-64Cu) or PEG-HAuNS-siRNA(DOTA-64Cu). Arrowheads indicate the tumors. Reproduced with permission from ref. .
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