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Chemists are contributing to incremental improvements of the conventional strategy by investigating and controlling electrode passivation layers, improving the rate of Li+ transfer across electrode/electrolyte interfaces, identifying electrolytes with larger windows while retaining a Li+ conductivity σLi > 10–3 S cm–1, synthesizing electrode morphologies that reduce the size of the active particles while pinning them on current collectors of large surface area accessible by the electrolyte, lowering the cost of cell fabrication, designing displacement-reaction anodes of higher capacity that allow a safe, fast charge, and designing alternative cathode hosts.
1840:Publication of Justus von Liebig's Thierchemie which united thefield of chemistry and physiology. He pointed out that that organic compoundsin plants are synthesized from carbon dioxide in the atmospherewhile nitrogenous compounds are derived from precursors in the soil.
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REDWOOD CITY, Calif.--()--, a company focused on the discovery and development of innovative drugs derived from natural compounds, today announced the publication of new research by the company’s scientific founder and scientific advisory board chairman, Martin D. Burke, M.D., Ph.D., professor of chemistry, University of Illinois at Urbana-Champaign, and Early Career Scientist of the Howard Hughes Medical Institute. The paper in the journal , titled “Synthesis of many different types of small molecules using one automated process,” demonstrates the automation and robust application of a unified “building blocks” approach for synthesizing multiple classes of complex natural chemicals that could be valuable backbones for new medicines.
SynArchive is a free web based application that allows you to browse a growing database of organic syntheses. Unlike most chemical synthesis shown on the web, the sequence of reactions is clear, precise and unambiguous.
ChemSynthesis - Chemical Database
ChemSynthesis is a freely accessible database of chemicals. This website contains substances with their synthesis references and physical properties such as melting point, boiling point and density. There are currently more than 40,000 compounds and more than 45,000 synthesis references in the database.
REVOLUTION Medicines, which its launch in February 2015, is building its industrial-scale REVBLOCKS™ drug discovery platform based on these methods under an exclusive license from the University of Illinois encompassing an extensive patent estate. Results announced today and featured on the cover of build on data by Dr. Burke and his research team regarding the successful manual application of this synthesis process to polyene compounds. The new results demonstrate that the approach can be automated and used to produce a broad range of molecules, including those containing diverse types of chemical bonds, as well as highly complex cyclic and polycyclic structures.
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The REVBLOCKS™ platform enables REVOLUTION Medicines to produce a pipeline of drug candidates with best-in-class properties based on the complex structures found in natural products. The company’s first drug candidates, also exclusively licensed from the University of Illinois, leverage and improve upon the biological activity of amphotericin B, a powerful, broad-spectrum antifungal compound found in nature that is used to treat patients with life-threatening fungal infections. The building block synthesis technology was essential to the genesis of these drug candidates in Dr. Burke’s laboratory. In addition to the REVBLOCKS system for enabling advanced medicinal chemistry on complex compounds, the company is developing its REVEAL™ informatics platform to draw structural and functional lessons from evolution to enrich for preferred natural scaffolds as chemical leads against disease targets.
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