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SYNTHESIS OF TN AND SIALYL TN ANTIGEN-LIPID A …

KW - STn antigen

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2. Synthesis of the Sialyl-Tn (sTn) Antigen - MDPI

Sialyl-Tn expression is associated with morphological changes, decreased growth and adhesion, and increased cell migration of sialyl-Tn positive clones.

carbohydrate antigen sialyl-Tn ..

Mucins from benzyl-α-GalNAc-treated cells had increased binding of peanut agglutinin (specific for T antigen, Galβ3GalNAc) and Vicia villosa agglutinin B4 (specific for Tn antigen, GalNAcα-Thr/Ser), but decreased binding of monoclonal antibodies 19-9, SNH3, and 91.9H (specific for sialyl Lea, sialyl Lex, and sulfomucin, respectively).

synthesis of cancer-associated sialyl-Tn ..

In mucins purified from the medium of treated cells, peripheral carbohydrate antigens (sialyl Le″ in KATO III and terminal fucose in Caco-2) were decreased (compared with control), while core carbohydrate antigens (T antigen in both cell lines and sialyl Tn in Caco-2) were increased.

Western blots of cell homogenates showed differences between KATO III and Caco-2 in MUC 1 apomucin protein antigens, in sialyl Lex and in sialyl Tn antigens.

synthesis of the cancer-associated sialyl-Tn ..

In situ hybridization demonstrated that the localization of transcripts correlated well with that of STn antigen in gastric cancer cells and Goblet cells in intestinal metaplastic glands (Ikehara et al., 1999).
RT-PCR analysis shows that ST6GalNAc I gene is expressed only in a limited number of cultured cancer cells, including HT29 and Dami cells (Figure 2).

The enzyme possess the 4 signature motifs (sialylmotifs L, S, VS and motif III) of mammalian sialyltransferases (Harduin-Lepers et al., 2005; Jeanneau et al., 2004) and the ST6GalNAc A family-motifs (Patel & Balaji, 2006).

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  • acid forming the structure referred to as the sialyl-Tn antigen.

    KW - Tn antigen

  • is referred to as the Tn antigen ..

    STn appears to be a more specific tumor marker in pancreas cancer than Tn antigen (Ching et al., 1994).

  • sialyl Lewis(x), and sialyl Tn ..

    Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen

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leads to the expression of T antigen or Tn and sialyl Tn ..

The enzyme transfers a sialic acid (N-acetylneuraminic acid) from CMP-NeuAc in the 6-position of a GalNAc residue linked to a serine or a threonine residue of a mucin-type glycopeptide or glycoprotein.

leads to the synthesis of siayl Tn antigen

Mucins from benzyl-α-GalNAc-treated cells had increased binding of peanut agglutinin (specific for T antigen, Galβ3GalNAc) and Vicia villosa agglutinin B4 (specific for Tn antigen, GalNAcα-Thr/Ser), but decreased binding of monoclonal antibodies 19-9, SNH3, and 91.9H (specific for sialyl Lea, sialyl Lex, and sulfomucin, respectively).

in the synthesis of the cancer-associated sialyl-Tn ..

These include peripheral antigens such as sialyl Lea and sialyl Lex and core region carbohydrate antigens such as T, Tn, and Sialyl Tn.

which results in the formation of sialyl-Tn antigen ..

The MKN45 gastric cell line stably transfected with the full length ST6GalNAc-I also showed high expression of Sialyl-Tn antigen (Marcos et al., 2004).

Epitope mapping of a new anti-Tn antibody detecting gastric cancer ..

In breast carcinomas, a complete correlation between the expression of ST6GalNAc-I and the expression of sialyl-Tn has been shown (Sewell et al., 2006).

and has a role in synthesis of the tumor-associated sialyl-Tn O ..

ST6GalNAc I is particularly involved in the biosynthesis of the sialyl-Tn antigen (STn, NeuAc-alpha2-6GalNAc-alpha1-O-Ser/Thr) and also participates to the biosynthesis of sialyl-6-T (Gal-beta1-3[NeuAc-alpha2-6]GalNAc-alpha1-O-Ser/Thr) and disialyl-T antigens (NeuAc-alpha2-3Gal-beta1-3[NeuAc-alpha2-6]GalNAc-alpha1-O-Ser/Thr) (Figure 4).
ST6GalNAc I compete with O-glycans elongating glycosyltransferases and prevent cancer cells to exhibit longer O-glycans.

for the synthesis of Sialyl-Tn antigen ..

While fetal and normal adult tissues weakly express STn, the antigen is over-expressed in a wide range of epithelial cancers and is considered as a good maker of tumor.

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