for steroid saponin biosynthesis in ..
L.: Priapism caused by 'Tribulus terrestris'.; Int J Impot Res 2016; 28: 39--40
Steroidal saponin biosynthesis Saponin - Wikipedia
Steroidal saponins are natural surfactants with various biological activities, and the tubers of , known as yam, contain a furostanol glycoside protodioscin and a spirostanol glycoside dioscin, which are valuable saponins required for semi-synthetic production of pharmaceutical steroidal drugs. Steroidal saponins are biosynthesized from cholesterol via several steps of oxygenation and transglycosylation, and a β-glucosidase is involved in the hydrolytic conversion from furostanol glycosides to spirostanol glycosides. To investigate steroidal saponin biosynthesis in spps, comparative transcriptome analysis of high saponin producers, and , and a low producer, , was performed using 454 pyrosequencing. In this study, we isolated and characterized a β-glucosidase (DeF26G1) from . The cDNA encodes a family 1 glucosidase, and the transcript was present at high levels in but not detected in . The recombinant DeF26G1 protein hydrolyzed the 26--glycosidic bond of protodioscin to form dioscin, indicating that the gene encodes furostanol glycoside 26--β-glucosidase. These results suggested that DeF26G1 is involved in the conversion of furostanol saponins to spirostanol saponins, which seems to be related to biological defense response in the leaves of plants.
K., Kadota S.: Hepatoprotective effect of majonoside R2, the major saponin from Vietnamese ginseng (Panax vietnamensis).; Planta Med 2002; 68: 402--406
Structural variety and biosynthesis
c.: Proerectile pharmacological effects of Tribulus terrestris extract on the rabbit corpus cavernosum; Ann Acad Med Singapore 2000; 29: 22--26
M., Aoki T.: Assessment of the Effects of Tribulus Terrestris on Sexual Function of Menopausal Women.; Rev Bras Ginecol Obstet 2016; 38: 140--146
Použitá vědecká literatura | Adaptogeny
k.: Evaluation of the aphrodisiac activity of Tribulus terrestris Linn - in sexually sluggish male albino rats; J Pharmacol Pharmacother 2012; 3: 43--47
O., Destro-saade R., Luiza-reis A., Fregonesi A.: Tribulus terrestris versus placebo in the treatment of erectile dysfunction: A prospective, randomized, double blind study.; Actas Urol Esp 2014; 38: 244--248
Natural Products - Compound Libraries
glyceryl tristearate, 555-43-1 - The Good Scents Company
Saponin - Wikipedia
TG(18:0/18:0/18:0) is a tristearic acid triglyceride
The aglycone (glycoside-free) portions of the saponins are termed sapogenins
Bi Syndromes - Summit Complementary Medicine
Glycoside - Wikipedia
CAPSICUM: Uses, Side Effects, Interactions and …
- Nakayasu M., Kawasaki T., Lee H.J., Sugimoto Y., Onjo M., Muranaka T., Mizutani M. (2015)
Identification of furostanol glycoside 26-O-β-glucosidase involved in steroidal saponin biosynthesis from .
, 32, 299–308.
Biosynthesis of Saponin Glycosides - Epharmacognosy
- Kohara A., Nakajima C., Yoshida S., Muranaka T. (2007)
Characterization and engineering of glycosyltransferases responsible for steroid saponin biosynthesis in Solanaceous plants.
, 68, 478–486.
Saponin biosynthesis Publications and Abstracts | …
- Kohara A., Nakajima C., Hashimoto K., Ikenaga T., Tanaka H., Shoyama Y., Yoshida S., Muranaka T. (2005)
A novel glucosyltransferase involved in steroid saponin biosynthesis in .
, 57, 225–239.
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