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2-phenyl-1,2-propanediol | C9H12O2 - ChemSynthesis
(S)-(-)-1,1-DIPHENYL-1,2-PROPANEDIOL CAS#: 46755 …
Eucalyptol (No. 1234) did not induce chromosomal aberrations in Chinese hamster ovary cells at concentrations ranging from 479 to 663 µg/ml without metabolic activation, and from 630 to 810 µg/ml with metabolic activation (Galloway et al., 1987). Diphenyl ether (No. 1255), at concentrations of 5 to 5000 µg/ml, did not induce chromosomal aberrations in Chinese hamster ovary cells with or without metabolic activation (SanSebastian, 1989).
Johnson, W.D., Ehrlich, J.P., Hatoum, N.S. & Yermakoff, J.K. (1992) Thirteen week oral toxicity study of diphenyl ether in rats. 12, 117.
(S)-(-)-1,1-DIPHENYL-1,2-PROPANEDIOL | 46755-94-6
Law, F.C.P. & Chakrabarti, S. (1983) Irreversible binding of 14C-diphenyl ether-derived radioactivity to liver microsomes and tissue proteins . 6, 285–294.
Komsta, E., Chu, I., Villeneuve, D.C., Benoit, F.M. & Murdoch, D. (1988) Tissue distribution metabolism and excretion of 2,2’,4,4’,5-pentachlorodiphenyl ether in the rat. 62, 258–262.
Howes, A.J., Chan, V.S.W. & Caldwell, J. (1990) Structure-specificity of the genotoxicity of some naturally occurring alkenylbenzenes determined by the unscheduled DNA synthesis in rat hepatocytes. 28, 537–542.
Birch, M. (1992) Toxicological investigations with diphenyl oxide in rats and rabbits. Submission to EPA. Unpublished report to the Flavor and Extract Manufacturers Association. Submitted to WHO by the Flavor and Extract Manufacturers Association of the United States, Washington DC, USA.
REFERENCE EXAMPLE 1 Synthesis of (S)-,1-diphenyl-1,2-propanediol
1.3- Diphenyl-1,3-propanediol esters 2- esters, ..
2-phenyl-1,2-propanediol - chemical structural formula, chemical names, chemical properties, synthesis references
ALIPHATIC AND AROMATIC ETHERS (JECFA 52, 2004)
2,2-diphenyl-1,3-propanediol - chemical structural formula, chemical names, chemical properties, synthesis references
09/04/1993 · 1.2 Estimated daily intake
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Toronto Research Chemicals - TRC Canada
In an abstract for a preliminary screening study that was not published, -methylanisole (No. 1243) was tested in an assay for unscheduled DNA synthesis in vitro using hepatocytes isolated from adult male Fischer or Sprague-Dawley rats. Positive responses were reported for -methylanisole, but only at cytotoxic concentrations (188 µg/ml; relative survival, 60–78%). At lower non-cytotoxic concentrations (5–100 µg/ml), there was no evidence of unscheduled DNA synthesis (Heck et al., 1989). Furthermore, incubation of the related substance -propylanisole (No. 1244) with rat hepatocytes showed no evidence of unscheduled DNA synthesis (Howes et al., 1990). Diphenyl ether gave negative results in two separate assays for unscheduled DNA synthesis in rat hepatocytes in vitro at concentrations ranging from 0.5 to 100 µg/ml (Mirsalis & Bakke, 1987) and from 0.1 to 1000 µg/ml(Farr, 1987a).
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Negative results were reported in the standard Ames assay when various strains of (TA97, TA98, TA100, TA102, TA1532, TA1535, TA1537, TA1538, TA1978 and TA2636) were incubated with eucalyptol (No. 1234), anisole (No. 1241), -methylanisole (No. 1243), -propylanisole (No. 1244), 1,2-dimethoxybenzene (No. 1248), -dimethoxybenzene (No. 1249), -dimethoxy-benzene (No. 1250), diphenyl ether (No. 1255), dibenzyl ether (No. 1256),naphthyl methyl ether (No. 1257),naphthyl ethyl ether (No. 1258), ornaphthyl isobutyl ether (No. 1259) at concentrations of up to 50 000 µg/plate, with and without metabolic activation (Clark et al., 1979; Florin et al., 1980; Rapson et al., 1980; Haworth et al., 1983; Pagano et al., 1983, 1988; Wild et al., 1983; Westinghouse Electric Corporation, 1984; Heck et al., 1989; Gomes-Carneiro et al., 1998).
Propane Dehydrogenation over Pt/TiO2–Al2O3 Catalysts …
In a 13-month study, groups of eight male albino rats were given diets containing either diphenyl ether only at an estimated daily intake of 530 mg/kg bw (0.5 cm3/kg bw) or as part of a mixture of diphenyl (26.4%) and diphenyl ether (73.6%) at estimated daily intakes of 137 and 396 mg/kg bw (0.5 cm3/kg bw), respectively. Histopathological examinations were performed on the liver, kidney, spleen, heart, lung, thyroid and parathyroid glands, adrenal glands, pancreas, testicles, stomach and intestines. No tumours were observed in the rats treated with either diphenyl ether alone or as part of the mixture. No control group was used in this study (Pecchiani & Saffiotti, 1957).
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Groups of five mated female Sprague-Dawley rats received a mixture (Therminol® VP-1) containing 73.5% diphenyl ether and 26.5% biphenyl at a single daily dose of 0, 100, 200, 400, 800, and 1500 mg/kg bw per day (approximately equivalent to dietary intakes of diphenyl ether of 0, 73.5, 147, 294, 588, and 1102 mg/kg bw per day, respectively) on days 6–15 of gestation. The animals were observed twice daily for clinical signs of toxicity and mortality, and food consumption was measured on days 0–20 of gestation. Body weights and clinical signs of toxicity were recorded on days 0, 6, 10, 12, 15 and 20 of gestation. The animals were sacrificed on day 20 of gestation and subjected to gross necropsy and examinations of corpora lutea and the uterus. Fetuses were weighed, sexed and examined for external malformations. Deaths were reported in 4/5 rats (80%) at 400 mg/kg bw per day during days 8–15 of gestation, and in 1/5 (20%) rats at 1500 mg/kg bw per day on day 15 of gestation. With the exception of the group receiving 400 mg/kg bw per day, in which the rate of pregnancy was 80%, the rate of pregnancy was reported to be 100% in all treatment groups. Rats receiving Therminol® at a dose of 400, 800, or 1500 mg/kg bw per day had staining of the fur in the ano-genital area, as well as signs of excessive salivation. Maternal body-weight gain was affected in a dose-related manner in the groups receiving Therminol® at a dose of 100, 200, or 800 mg/kg bw per day, and weight loss was reported in rats at 1500 mg/kg bw per day. Maternal food consumption was decreased at all doses when compared with that of the controls during days 6–15 of the treatment period; however, during the post-treatment period (days 15–20 of gestation), food consumption and weight gain at all doses were reported to be significantly greater than those of controls. There were no significant differences in the number of corpora lutea, uterine implantation sites, or preimplantation loss indices reported between rats treated with Therminol® and rats in the control groups. The mean number of viable fetuses and resorptions per dam did not differ significantly at 100, 200, or 400 mg/kg bw per day or in controls. Significantly increased frequencies of uterine resorptions and significantly decreased numbers of viable fetuses per litter were reported at 800 mg/kg bw per day. Fetal weights at 1500 mg/kg bw per day were significantly lower than those of controls. No treatment-related effects were noted upon gross examinations of the dams. An external malformation (unilateral microphthalmia) was noted in one of the fetuses of the group receiving a dose of 800 mg/kg bw per day; however, no fetal malformations were reported in the other treated groups (Farr, 1987b).
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