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Synthesis of 3aH-isoxazolo-[5, 4-d]-pyrimidin-6-ones (11-13):

T1 - Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors

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Synthesis of pyrazolo-pyrimidinones (14 and 15):

Synthesis of Azepinoindoles via Rhodium-Catalyzed Formal Aza-[4 + 3] Cycloaddition Reaction of 3-Diazoindolin-2-imines with 1,3-Dienes in One-Pot 2017,

T1 - Synthesis and radioprotective effects of adamantyl substituted 1,4-dihydropyridine derivatives
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Diethon (2,6-Dimethyl-3,5-Diethoxy-carbonyl-1,4-Dihydropyridine) is a special anti-burn agent which has a high antioxidant effect, it normalizes oxidation-reduction processes in the skin during and after tanning, stimulates regeneration of skin tissues.

Exforge is a fixed combination of amlodipine and valsartan

General procedure for the synthesis of 1, 4-dihydropyridinederivatives (5a-i)
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In this study novel 1, 4-dihydropyridine derivatives were prepared according toHantzsch reaction and evaluated for in vitro COX-1/COX-2 isozyme inhibition. We alsoperformed docking studies to determine the orientation of the synthesized compoundsin the COX-2 active site which led to the better understanding of thestructure-activity relationship in designed COX-2 inhibitors.

Palladium-catalyzed direct arylation reactions are described with a broad range of azine and azole -oxides. In addition to aspects of functional group compatibility, issues of regioselectivity have been explored when nonsymmetrical azine -oxides are used. In these cases, both the choice of ligand and the nature of the azine substituents play important roles in determining the regioisomeric distribution. When azole -oxides are employed, preferential reaction is observed for arylation at C2 which occurs under very mild conditions. Subsequent reactions are observed to occur at C5 followed by arylation at C4. The potential utility of this methodology is illustrated by its use in the synthesis of a potent sodium channel inhibitor 1 and a Tie2 Tyrosine Kinase inhibitor 2.

Design and synthesis of 1,4-dihydropyridine derivatives …

Synthesis of 5- acyl- 4- aryl- 6- methyl- 3, 4-dihydropyrimidinones (1- 4 and 18):
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Indium-Mediated 1,2,4,5-Hexatetraen-3-ylation of 4-Acetoxy-2-azetidinones and Their Applications to the Diels-Alder Reactions for the Synthesis of 2-Azetidinone Derivatives, 2008,

Selective Indium-Mediated 1,2,4-Pentatrien-3-ylation of Carbonyl Compounds for the Efficient Synthesis of Vinyl Allenols, 2008,

Platinum-Catalyzed Intramolecular Hydroarylation of Allenyl Arenes: Efficient Synthesis of 1,4-Dihydronaphthalenes, 2010,
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  • Oxidation of dihydropyridine by DDQ - ChemTube3D

    KW - Dihydropyridine

  • Oxidation of dihydropyridine by DDQ in pyridine synthesis

    KW - 1,4-Dihydropyridine


    Design and Synthesis of 1,4-Dihydropyridine and Cinnamic Acid Esters and Their Antioxidant Properties[J].

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One-step synthesis of pyridines and dihydropyridines in …

A particular problem in the nomenclature and stereochemical designation of semisynthetic compounds occurs as both the above systems may be used to define the structure of a single molecule. For example, the absolute stereochemistry of the 6-aminopenicillanic acid and 7-aminocephalosporanic acid nucleii have been determined and defined using the R/S system but the addition of a side chain, e.g. Ampicillin, Cephalexin may result in the introduction of an additional chiral centre, which in the case of these two compounds is frequently defined in terms of the D/L system.

US5216172A - 1,4-dihydropyridine-4-aryl-2,6-dimethyl …

Synthesis of the hydrazonoethyl derivatives 16 and 17: A mixture consisting of any of the acetyl derivatives 2 or 4 (10 mmol), dioxane (30 mL) and hydrazine hydrate (2 mL) was heated under reflux for 6 h. The solvent was removed under reduced pressure and the residual product was treated with water, filtered, washed with water, dried and crystallized from ethanol to give the title compounds 16 and 17.

Patent US4985558 - 1,4-dihydropyridine derivative - …

In conclusion, new 1, 4-dihydropyridine derivatives were synthesized and evaluatedfor COX-1/COX-2 inhibition. Among them, compound 5e exhibited good COX-2 inhibitoryactivity and selectivity (IC50=0.30 μM and COX-2 selectivity index=92).Experimental results in conjunction with molecular docking studies indicated thatcompound 5e with methyl and ethoxycarbonyl groups as R1 andCOOR2 substitutionscould interactappropriately with COX-2 activesite. Therefore, this compound provides a promising lead for further development.

1 4 dihydropyridine synthesis essay - Hot Tub Hire …

A group of 1,4-dihydropyridine derivativespossessing a MeSO2 at thepara-position of the C-4 phenyl ring, alkylgroups(R1) at the C-2 position and alkyloxycarbonylgroups(COOR2) at the C-3 position were prepared and evaluated fortheir ability to inhibit COX-1 and COX-2 using chemiluminescent kit (Caymanchemical, MI, USA) according to our previously reported method (). Potent and selective COX-2 inhibitor,celecoxib was used as a reference compound inthe COX activity assay. All experimentswere carried out at leastthree times and the data of inhibitory effects weresummarized in .

Piperidinium to 3,4-Dihydropyridine Full Text; PDF (148 kb) ..

Stereoselective Synthesis of 4-Alkyl- or 4-Aryl-3-ethoxycarbonyl-2-halo-1,3-dienes from the Reaction of Allenols Having Ethoxycarbonyl Group with Indium Trihalide, 2009,

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