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retinoic acid synthesis in Xenopus ..

-Retinoic acid

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13-cis-Retinoic acid 98% | Sigma-Aldrich

27. Ishibashi T, Nakazawa M, Ono H, Satoh N, Gojobori T, Fujiwara S. Microarray analysis of embryonic retinoic acid target genes in the ascidian . 2003;45:249-259

Isotretinoin is a naturally-occurring retinoic acid with potential antineoplastic activity

Synthesis, degradation and mode of action of retinoic acid (RA). A) The metabolic pathway for synthesis and degradation of endogenous RA is shown. RA is synthesized by oxidation of retinal by retinaldehyde dehydrogenases (RALDHs). In a reversible reaction, retinal is synthesized from retinol (vitamin A) by either aldehyde dehydrogenases (ADHs) or short-chain dehydrogenase/reductases (RDHs/SDRs). Cellular retinol binding proteins (CRBPs) can bind retinol, whereas cellular retinoic acid binding proteins (CRABPs) can bind RA. Finally, endogenous RA is degraded by CYP26 enzymes. B) The RAR/RXR heterodimer mediates the effects of RA. In the absence of ligand (RA), the RAR/RXR heterodimer is bound to DNA and co-repressors. This complex induces transcriptional repression through histone deacetylation. Binding of the ligand (RA) induces conformational changes and the binding of co-activators leading to histone acetylation and activation of transcription.

The synthesis of 13-cis-retinoic acid-6,7-14C - …

36. Mark M, Ghyselinck NB, Chambon P. Retinoic acid signalling in the development of branchial arches.  2004;14:591-598

38. Dupe V, Ghyselinck NB, Wendling O, Chambon P, Mark M. Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse. 1999;126:5051-5059

33. Kuno S, Kawamoto M, Okuyama M, Yasumasu I. Outgrowth of pseudopodial cables induced by all-trans retinoic acid in micromere-derived cells isolated from sea urchin embryos. 1999;41:193-199

Retinoic Acid Synthesis and Metabolism | SpringerLink

30. Nagatomo K, Fujiwara S. Expression of ,  and  in normal and retinoic acid-treated  embryos.  2003;3:273-277

14. Escriva H, Holland ND, Gronemeyer H, Laudet V, Holland LZ. The retinoic acid signaling pathway regulates anterior/posterior patterning in the nerve cord and pharynx of amphioxus, a chordate lacking neural crest. 2002;129:2905-2916

12. Holland LZ, Holland ND. Expression of and in amphioxus embryos treated with retinoic acid: insights into evolution and patterning of the chordate nerve cord and pharynx. 1996;122:1829-1838

57. Hinman VF, Degnan BM. Retinoic acid perturbs  gene expression in the ascidian pharynx.  2000;210:129-139
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  • 13-CIS-RETINOIC-ACID - Lookchem

    Retinoic acid - Wikipedia

  • Isotretinoin (13-cis-Retinoic Acid) | SpringerLink

    Retinoic acid is a metabolite of vitamin A that mediates the functions of vitamin A required for growth and development

  • All-trans-Retinoic Acid in Acute Promyelocytic Leukemia …

    18/12/2017 · A route to crystalline 13-cis-retinoic acid-6,7-14C (1) has been developed

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Retinoic acid signaling and the evolution of chordates

Ferdinand Marlétaz, B.S., M.A.-I (Ecole Normale Supérieure de Lyon, France), is a graduate student in the Laboratory of Molecular Biology of the Cell at the Ecole Normale Supérieure in Lyon, France. He is currently working on the identification of molecular components of the retinoic acid signaling cascade in invertebrate chordates. He is mainly interested in defining novel characters (morphological or molecular) to improve our current understanding of the phylogenetic relationships between animals.

Retinoic acid signaling and the evolution of chordates

58. Hinman VF, Degnan BM. Retinoic acid disrupts anterior ectodermal and endodermal development in ascidian larvae and postlarvae. 1998;208:336-345

All- trans -Retinoic Acid in Acute Promyelocytic Leukemia

52. Schubert M, Yu JK, Holland ND, Escriva H, Laudet V, Holland LZ. Retinoic acid signaling acts via Hox1 to establish the posterior limit of the pharynx in the chordate amphioxus. 2005;132:61-73

4-Keto 13-cis-retinoic acid | 71748-58-8 | Carbosynth …

50. Matt N, Ghyselinck NB, Wendling O, Chambon P, Mark M. Retinoic acid-induced developmental defects are mediated by RARβ/RXR heterodimers in the pharyngeal endoderm. 2003;130:2083-2093

Retinoic Acid Synthesis in the Postnatal Mouse Brain …

44. Kuratani S, Ueki T, Hirano S, Aizawa S. Rostral truncation of a cyclostome, , induced by all- retinoic acid defines the head/trunk interface of the vertebrate body. 1998;211:35-51

13-(Z)-Retinoic acid is prepared by a) ..

42. Niederreither K, Vermot J, Le Roux I, Schuhbaur B, Chambon P, Dolle P. The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system. 2003;130:2525-2534

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