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Method Princip Med Chem 2005;24:223–41.

Scott D. Rychnovsky et al., J. Am. Chem. Soc., 2011, Article ASAP; [] [] []

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US NIOSH (1984a) Analytical method 2500: 2-butanone.

Effects of methyl ethyl ketone on aquatic organisms Species Concentration Effects and comments pH Temperature Hardness Reference (mg/litre) (°C) Crustacea Artemia salina 1950 24-h LC50, bottles not not given not given not given Price et al.

The clearance of MEK and its metabolites in mammals is essentially complete in 24 h.

STEL (average value, 4 x per shift) Hungary 200 (68) TWA (8 h) IRPTC (1987, 1991) 1000 (2950) STEL (30 min) Italy 590 (200) TWA Notified by country Japan 590 (200) TWA IRPTC (1987, 1991) Netherlands 590 (200) TWA a Sweden 150 (50) TWA IRPTC (1987, 1991) 300 (100) STEL (15 min) United Kingdom 590 (200) TWA (8 h), OES Notified by country 885 (300) STEL (10 min), OES USA (NIOSH/OSHA) 590 (200) TWA (10 h) US NIOSH (1990) 885 (300) STEL (15 min) 8850 (3000) IDLH USA (ACGIH) 590 (200) TLV (TWA) ACGIH (1991) 885 (300) STEL 2 mg/litre BEI urine; end of shift Yugoslavia 295 (100) Notified by county TWA and TLV are, with one exception, in the range of 295-590 mg/m3 (100-200 ppm).

ethyl 2-methyl butyrate, 7452-79-1 - The Good Scents …

In a study of compounds related to milk flavour, Wong & Patton (1962) determined MEK concentrations using the DNPH method with column separation and paper chromatography.

KINETICS AND METABOLISM 6.1.1 Percutaneous absorption Percutaneous absorption of MEK appears to be rapid (Munies & Wurster (1965) and Wurster & Munies (1965) reported that MEK was present in the exhaled air of human subjects within 2.5-3.0 min after it was applied to normal skin of the forearm, and the concentration of MEK in exhaled air reached a plateau in 2-3 h.

5-Methyl-2-hexanone is found in animal foods

This gives a percutaneous absorption of 5-10 µgÊcm-2Êmin-1, which is identical to the value measured for methyl isobutyl ketone by DiVincenzo et al.

It is rapidly metabolized by mammals (Di Vincenzo et al., 1976, 1978; Dietz et al., 1981; Miyasaka et al., 1982) and by many microbes (Gerhold & Malaney, 1966; Dojlido, 1977; Urano & Kato, 1986).

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  • N-Methyl-2-Pyrrolidone (NMP) | TDS | Eastman …

    (1976) identified the metabolites of MEK in guinea-pigs as 2-butanol, 3-hydroxy-2-butanone and 2,3-butanediol.

  • Methyl ethyl ketone (EHC 143, 1992) - IPCS INCHEM

    Other metabolites of MEK, 2-butanol or 2,3-butanediol, which DiVincenzo et al.

  • CAS No.628-44-4,2-Octanol, 2-methyl- Suppliers - …

    The urinary excretion of 2-butanol, a minor metabolite of MEK, was examined by Kamil et al.

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2-Octanol, 2-methyl- MSDS CasNo.628-44-4 - Lookchem

MEK has been reported to be a metabolic end product of natural gas (methane 88%, ethane 5%, propane 5%, isobutane 2% with traces of tert-butyl mercaptan and methyl acrylate) inhaled for 2 h by ICR mice (Tsukamoto et al., 1985a).

1-iodo-2-methyl-2-octanol | C9H19IO - ChemSynthesis

It also has been reported in chicken breast muscle (Grey & Shrimpton, 1967), weed residues (Bradow & Connick, 1988), southern pea seeds (Fisher et al., 1979), insect pheromones (Cammaerts et al., 1978; Attygalle et al., 1983), juniper leaves (Khasanov et al., 1982); marine macroalgae (seaweeds) (Whelan et al., 1982) and as a product of microbial metabolism (Patel et al., 1982; Mohren & Juttner, 1983; Zechman et al., 1986), including cultures isolated from fresh water and soil (Hou et al., 1983; Patel et al., 1983).

High-Temperature Study of 2-Methyl Furan and 2-Methyl …

Experimental data and equations derived from this data indicated that the major metabolic pathway is butanol -> MEK -> 3-hydroxy-2-butanone -> 2,3-butanediol, with small or non-existent reverse flows.

1-(1,3-benzothiazol-2-yl)-2-methyl-2-octanol | …

For MEK in blood the United States National Institute of Occupational Safety and Health method (US NIOSH, 1984b), using GC/FID, has a detection limit of 20 µg/litre and the Ramsey & Flanagan (1982) method has a detection limit of 100 µg/litre.

2-METHYL-2-OCTANOL CAS#: 628-44-4

It is likely that 2-butanol, like ethanol (Mezey, 1976), inhibits oxidative pathways of drug metabolism and thus inhibits the hydroxylation step leading to 3-hydroxy-2-butanone.


In a similar study of workers occupationally exposed to a mixture of solvents, the excretion of MEK and a major recognizable metabolite, 3-hydroxy-2-butanone, was 0.1% of alveolar uptake (Perbellini et al., 1984).

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