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EP0335586B1 - Piperidine & piperazine derivatives, …

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4-chlorophenyl, 4-chlorophenyl Suppliers and …

The most similar structure to the claimed compounds are dihydrochloride 2-(4-methoxyphenyl)-4-morpholinomethyl-3-phenyl-(IIA) and 4-(2-diethylaminoethyl)-2-(4-chlorophenyl)-3-phenylpyrrole[1,2-a]benzimidazole (IIB), exhibiting antioxidant activity (VAIDISOVA, Spa and other Synthesis and pharmacological activity of salts of 4-(2-dialkylaminomethyl)pyrrolo[1,2-a]benzimidazole. Chem.-Pharm. journal, 1996, C. No. 1, s-25). However, their activity is still not high enough.

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and pharmaceutically acceptable salts and solvates thereof, in which R1 is an optionally substituted alkyl or similar, R2 is a group of formula: -Y-R5, where Y is -O- or S; R5 is a substituted alkyl (the substitute is an optionally substituted cycloalkyl or similar), a branched alkyl or similar; R4 is hydrogen or C1-10 alkyl; R3 is a group of formula: -C(=O)-Z-R6, where Z is -NR7- or -NR7-W-; R6 is an optionally substituted cycloalkyl or similar; R7 is hydrogen or C1-10 alkyl, W is C1-10 alkylene; X is =N- provided that a compound in which R2 is 2-(4-morpholino)ethoxy, 2-, 3- or 4-pyridylmethoxy, 1-methylpiperidinyl-2-methoxy, benzyloxy or 4-substituted benzyloxy is excluded; and R3 is N-(1-adamantyl)carbamoyl, N-(2-adamantyl)carbamoyl and N-(3-noradamantyl)carbamoyl. Said compound is an 11β-hydroxysteroid dehydrogenase type 1 inhibitor. The invention also relates to a pharmaceutical composition containing said compound as an active ingredient.

(4-Chlorophenyl)-2-pyridylmethoxy]piperidine p ..

Customization Betahistine Intermediates HPLC: …

and pharmaceutically acceptable salts and solvates thereof, in which R1 is an optionally substituted alkyl or similar, R2 is a group of formula: -Y-R5, where Y is -O- or S; R5 is a substituted alkyl (the substitute is an optionally substituted cycloalkyl or similar), a branched alkyl or similar; R4 is hydrogen or C1-10 alkyl; R3 is a group of formula: -C(=O)-Z-R6, where Z is -NR7- or -NR7-W-; R6 is an optionally substituted cycloalkyl or similar; R7 is hydrogen or C1-10 alkyl, W is C1-10 alkylene; X is =N- provided that a compound in which R2 is 2-(4-morpholino)ethoxy, 2-, 3- or 4-pyridylmethoxy, 1-methylpiperidinyl-2-methoxy, benzyloxy or 4-substituted benzyloxy is excluded; and R3 is N-(1-adamantyl)carbamoyl, N-(2-adamantyl)carbamoyl and N-(3-noradamantyl)carbamoyl. Said compound is an 11β-hydroxysteroid dehydrogenase type 1 inhibitor. The invention also relates to a pharmaceutical composition containing said compound as an active ingredient.

Synthesis intermediates for active pharmaceutical ingredients

(4-Chlorophenyl)-2-pyridylmethoxy]piperidine p-nitrobenzoic acid salt ..

Advanced intermediates - 重庆中基进出有限公司-化医
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  • Example 1 Synthesis of 1-[3-(4-acetyl-3-hydroxy-2-n ..

    Synthesis intermediates;

  • Anti-Allergic Intermediate - Conbott Pharm

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  • Product categories of Anti-Allergic Intermediate, ..

    Intermediates Name

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