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Experimental Biology 2017April 22 - 26, 2017Chicago, IL

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2018 AAAS Annual Meeting February 15 - 19, 2018Austin, TX

Maserati E, Pressato B, Valli R, MinelliA, Sainati L, Patitucci F, Marletta C, Mastronuzzi A, Poli F, LoCurto F, et al: The route to development of myelodysplasticsyndrome/acute myeloid leukaemia in Shwachman-Diamond syndrome: Therole of ageing, karyotype instability, and acquired chromosomeanomalies. Br J Haematol. 145:190–197. 2009. : :

Chiaki Ohara, Teruhisa Hongo, , Toshio Nagoya

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Loreni F, Mancino M and Biffo S:Translation factors and ribosomal proteins control tumor onset andprogression: How? Oncogene. 33:2145–2156. 2014. :

Naora H, Takai I, Adachi M and Naora H:Altered cellular responses by varying expression of a ribosomalprotein gene: Sequential coordination of enhancement andsuppression of ribosomal protein S3a gene expression inducesapoptosis. J Cell Biol. 141:741–753. 1998. : :

/ Ohara, Chiaki; Hongo, Teruhisa; Nagoya, Toshio.

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Robledo S, Idol RA, Crimmins DL, LadensonJH, Mason PJ and Bessler M: The role of human ribosomal proteins inthe maturation of rRNA and ribosome production. RNA. 14:1918–1929.2008. : :

Ligation yields clusteredindependent of coding sequence for the10 example sequences of each set, suggesting that the remaining 62set 1 and 66 set 2 members will behave similarly. Furthermore, electrophoreticanalysis of the ligation reaction products verified that ligase catalyzedat most one module ligation per site on solid supports. Some overhangs,while meeting the thermodynamic constraints, proved problematic inligation assays; for example, the trinucleotide overhang 5′-CTG-3′resulted in overhang homoligation and concomitant addition of twomodules, highlighting the need to validate overhangs experimentally.

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  • Examples of ribosomal protein genemutations in human tumors.

    Synthesis - Wikipedia

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    Modern synthesis - Wikipedia

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    Protein Synthesis -Translation and Regulation

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2016 Impact Factor: Ranked (total number of cites)

Ferreira-Cerca S, Pöll G, Kühn H, NeuederA, Jakob S, Tschochner H and Milkereit P: Analysis of the in vivoassembly pathway of eukaryotic 40S ribosomal proteins. Mol Cell.28:446–457. 2007. : :

Theauthorsdeclare no competing financial interest.

Kenmochi N, Kawaguchi T, Rozen S, Davis E,Goodman N, Hudson TJ, Tanaka T and Page DC: A map of 75 humanribosomal protein genes. Genome Res. 8:509–523. 1998.

Synthesis of (-)-Tetrodotoxin - Organic chemistry

Ban N, Beckmann R, Cate JH, Dinman JD,Dragon F, Ellis SR, Lafontaine DL, Lindahl L, Liljas A, Lipton JM,et al: A new system for naming ribosomal proteins. Curr Opin StructBiol. 24:165–169. 2014. : :

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Ferreira-Cerca S, Pöll G, Gleizes PE,Tschochner H and Milkereit P: Roles of eukaryotic ribosomalproteins in maturation and transport of pre-18S rRNA and ribosomefunction. Mol Cell. 20:263–275. 2005. : :

Bile Acid Synthesis, Metabolism and Biological Functions

Slavov N, Semrau S, Airoldi E, Budnik Band van Oudenaarden A: Differential stoichiometry among coreribosomal proteins. Cell Rep. 13:865–873. 2015. : :

Bile Acid Synthesis and Utilization

In addition to ligase biochemistry, a second source of encodinglanguage design constraints derived from the downstream analyticallimitations of current high-throughput DNA sequencing. While the readlengths of these instruments are relatively short (100–200bases), a single analysis can yield >107 of such readsin hours and for ∼$1000. The 6-position code design meets thisconstraint in producing encoded messages that require a maximum readlength of 98 bases: a 27-base forward primer, 12 bases for the firstand sixth positions, 11 bases each for positions 2–5, and 4bases downstream of the message for alignment. Discarding coding sequencesthat contain >3-base homopolymeric runs eliminates the highestsourceof error for pyrosequencing-based platforms., Finally,the minimum Hamming string distance of 3 between any two coding regionsdrastically diminishes the probability of random sequencing errorsobfuscating the actual coding region identity. At least two sequencingerrors within any coding region must occur to render the sequenceunintelligible for decoding. The probability of such errors is platformdependent, but an average substitution error rate of 0.1% translatesto a probability of 6 × 10–5, an insignificantfraction of total reads.

The end products of cholesterol utilization are the bile acids

Novetsky AP, Zighelboim I, Thompson DM Jr,Powell MA, Mutch DG and Goodfellow PJ: Frequent mutations in theRPL22 gene and its clinical and functional implications. GynecolOncol. 128:470–474. 2013. :

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