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Dicyclomine Hydrochloride is a synthetic tertiary amine antispasmodic

Simultaneous estimation of mefenamic acid and dicyclomine hydrochloride by RP-HPLC method.

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Overview of Dicyclomine Hydrochloride

The proposed method was found to have linearity in concentration range of 10-100 μg/ml for dicyclomine hydrochloride, 0.05-10 μg/ml for mefenamic acid and 0.1-20 μg/ml for paracetamol.

Use of π Acceptors for spectrophotometric determination of dicyclomine hydrochloride.

The proposed method was found to have linearity in concentration range of 10–100 μg/ml for dicyclomine hydrochloride, 0.05-10 μg/ml for mefenamic acid and 0.1−20 μg/ml for paracetamol.

Medical uses A 10-mg oral capsule of dicyclomine hydrochloride, ..

Simultaneous estimation of mefenamic acid and dicyclomine hydrochloride by spectroscopic methods.

Flavoxate hydrochloride tablets are not indicated for definitive treatment, but are compatible with drugs used for the treatment of urinary tract infections.



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DOSAGE AND ADMINISTRATION:
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Adults and children over 12 years of age

One or two 100 mg tablets 3 or 4 times a day.

ABSTRACT: Transdermal drug delivery system (TDS) is not practically for delivery of materials whose final target is skin itself. Application topical agents generally offer many problems such as rashes, skin irritancy and burning sensation etc due to higher percutaneous absorption of drugs on the skin. Some conventional dosage e.g., gels and ointments which are often aesthetically unappealing, greasiness and stickiness etc. that often result into lack of patient compliance. For reduce this side effects, microsponge technology offers many advantage over the conventional drug delivery. The microsponge based drug delivery system is a unique technology for controlled release and enhanced drug deposition in the skin while minimizing transdermal penetration of topically active agents. Drug loaded microsponge consist of microporous beads, typically 10-25 μm in diameter. Microsponge delivery system (MDS) can provide increased efficacy for topically active agents with enhanced safety, extended product stability, enhanced formulation flexibility, reduced side effects and improved aesthetic properties in an efficient and novel manner. In addition these are non-irritating, non-allergenic, non-mutagenic, and non-toxic. MDS technology is being used currently in cosmetics, over-the-counter skin care, sunscreen and prescription products.

Sigma brand OF dicyclomine hydrochloride: MeSH: Chemical Formula: ..

Mefenamic acid 250mg+ Paracetamol 325mg+ Dicyclomine Hydrochloride 10mg

Because many drugs are excreted in human milk, caution should be exercised when flavoxate hydrochloride is administered to a nursing woman.

Pediatric Use
Safety and effectiveness in children below the age of 12 years have not been established.


The following adverse reactions have been observed, but there are not enough data to support an estimate of their frequency.

Gastrointestinal: Nausea, vomiting, dry mouth.

CNS: Vertigo, headache, mental confusion, especially in the elderly, drowsiness, nervousness.

Hematologic: Leukopenia (one case which was reversible upon discontinuation of the drug).

Cardiovascular: Tachycardia and palpitation.

Allergic: Urticaria and other dermatoses, eosinophilia and hyperpyrexia.

Ophthalmic: Increased ocular tension, blurred vision, disturbance in eye accommodation.

Renal: Dysuria.

DOSAGE FORMS AND STRENGTHS:
Flavoxate hydrochloride 100 mg tablets are available as white, round biconvex, film-coated tablets, debossed “?

In order to minimize the appearance of cardiac side effects, the drugs may be administered simultaneously by intravenous injection and may be mixed in the same syringe.

Peptic Ulcer
Glycopyrrolate Injection is not recommended for the treatment of peptic ulcer in pediatric patients (see PRECAUTIONS – Pediatric Use).

Diluent Compatibilities
Dextrose 5% and 10% in water, or saline, dextrose 5% in sodium chloride 0.45%, sodium chloride 0.9%, and Ringer’s Injection.

Diluent Incompatibilities
Lactated Ringer’s solution


CONTRAINDICATIONS:
Glaucoma; obstructive uropathy (for example, bladder neck obstruction due to prostatic hypertrophy); obstructive disease of the gastrointestinal tract (as in achalasia, pyloroduodenal stenosis, etc.); paralytic ileus; intestinal atony of the elderly or debilitated patient; unstable cardiovascular status in acute hemorrhage; severe ulcerative colitis; toxic megacolon complicating ulcerative colitis; myasthenia gravis.

Electrochemical Investigation of Dicyclomine Hydrochloride at Poly (Terbutaline Sulphate) Modified Carbon Paste Electrode
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  • mefenamic acid along with dicyclomine hydrochloride as an ..

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Search results for Dicyclomine Hydrochloride at Sigma-Aldrich

Tests for mydriatic effects in mice showed that dicyclomine was approximately 1/500 as potent as atropine; antisialagogue tests in rabbits showed dicyclomine to be 1/300 as potent as atropine.

INDICATIONS AND USAGE:
BENTYL® (dicyclomine hydrochloride) is indicated for the treatment of patients with functional bowel/irritable bowel syndrome.

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DOSAGE AND ADMINISTRATION:
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Dosage must be adjusted to individual patients needs.

Oral Dosage and Administration in Adults
The recommended initial dose is 20 mg four times a day.

DICYCLOMINE HYDROCHLORIDE CAS#: 67-92-5

Applications: Microsponges are used mostly for topical and recently for oral administration as well as biopharmaceutical delivery. It offers the formulator a range of alternatives to develop drug and cosmetic products. These are developed to deliver an active ingredient efficiently at the low dose and also to enhance stability, reduce side effects and modify drug release 32 (Various applications are shown in table 1).

Diphenhydramine is an antihistamine mainly used to treat allergies

Dicyclomine hydrochloride (Sigma-Aldrich, St. Louis, MO), a selective muscarinic cholinergic M1 receptor antagonist, was dissolved in isotonic saline and administered intraperitoneal (i.p.) in a 5mg/kg dose (volume 1.0mL/kg) five minutes prior to induction of the TBI. The vehicle-treatment group received an equal volume i.p. injection of isotonic saline. Both groups received injections at the same time points relative to the injury, with the identity of the drug or vehicle concealed to the investigators. Drug dosing was based upon a previous TBI study which demonstrated behavioral protection with 1 or 10mg/kg dicyclomine (Robinson et al., ).

hydrochlorothiazide/propranolol hydrochloride - …

If a patient experiences anticholinergic CNS effects, dose reduction or drug discontinuation should be considered.

Reduced Hepatic and Renal Function
For patients with significantly reduced hepatic function or renal function, the recommended dose of DETROL is 1 mg twice daily (see package insert: CLINICAL PHARMACOLOGY, Pharmacokinetics in Special Populations).

Myasthenia Gravis
DETROL should be used with caution in patients with myasthenia gravis, a disease characterized by decreased cholinergic activity at the neuromuscular junction.

Patients with Congenital or Acquired QT Prolongation
In a study of the effect of tolterodine immediate release tablets on the QT interval (see package insert - CLINICAL PHARMACOLOGY, Cardiac Electrophysiology), the effect on the QT interval appeared greater for 8 mg/day (two times the therapeutic dose) compared to 4 mg/day and was more pronounced in CYP2D6 poor metabolizers (PM) than extensive metabolizers (EMs).

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