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Iron oxides are chemical compounds composed of iron and oxygen

Keywords: nanoparticles, iron oxide, gold, contrast agents, MRI, optical imaging, miRNA delivery, theranostics.

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Superparamagnetic Iron Oxide Nanoparticles as MRI …

N2 - We report a facile one-step hydrothermal approach to the synthesis of iron oxide (Fe3O4) nanoparticles (NPs) with controllable diameters, narrow size distribution, and tunable magnetic properties. In this approach, the iron oxide NPs were synthesized by oxidation of FeCl 2·4H2O in basic aqueous solution under an elevated temperature and pressure. Transmission electron microscopy and X-ray diffraction studies reveal that the particles are highly crystalline and that the diameters of the particles can be tuned from 15 to 31 nm through the variation of the reaction conditions. The NPs exhibit high saturation magnetization in the range of 53.3-97.4 emu/g and their magnetic behavior can be either ferromagnetic or superparamagnetic depending on the particle size. A superconducting quantum interference device magnetorelaxometry study shows that the size of the NPs significantly affects the detection sensitivity. The investigated iron oxide NPs may find many potential biological applications in cancer diagnosis and treatment.

T1 - Facile hydrothermal synthesis of iron oxide nanoparticles with tunable magnetic properties

63. Gao F, Cai Y, Zhou J, Xie X, Ouyang W, Zhang Y, Wang X, Zhang X, Wang X, Zhao L, Tang J. Pullulan acetate coated magnetite nanoparticles for hyperthermia: preparation, characterization and experiments. 2010;3:23-31

Multifunctional Iron Oxide Nanoparticles for …

120. Wen X, Yang J, He B, Gu Z. Preparation of monodisperse magnetite nanoparticles under mild conditions.  2008;8:535-41

79. Kim TH, Kim JK, Shim W, Kim SY, Park TJ, Jung JY. Tracking of transplanted mesenchymal stem cells labeled with fluorescent magnetic nanoparticle in liver cirrhosis rat model with 3-T MRI. 2010;28:1004-13

78. Lu CW, Hung Y, Hsiao JK, Yao M, Chung TH, Lin YS, Wu SH, Hsu SC, Liu HM, Mou CY, Yang CS, Huang DM, Chen YC. Bifunctional magnetic silica nanoparticles for highly efficient human stem cell labeling. 2007;7:149-54

Curing cancer with magnetic nanoparticles and …

Polysaccharides, especially those from natural sources, exhibit many specific properties compared to other materials, including water-solubility, biocompatibility, biodegradability, biological activity and low cost []. Polysaccharides enriched with hydroxyl groups have been reported to interact with iron oxide via hydrogen bonding []. Chitosan, pullulan, and heparin are the currently used polysaccharides for coating SPIONs.

While ferromagnetic particles such as Fe can be imaged with MRI, the contrast is much less than the contrast that can be achieved with SPIO nanoparticles. In this paper we describe the production of advanced nanoparticles, with a single-domain core of pure iron covered with 3–4 nm of iron oxide. The idea is to exploit the likely higher SAR of pure iron (compared to iron oxides) for heating, while using the film of superparamagnetic iron oxide for imaging of the nanoparticles.

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    Keywords: stem cells, superparamagnetic iron oxide nanoparticles, labeling, tracking, magnetic resonance imaging.

  • Iron Oxide Nanoparticles Magnetic Drug Delivery

    and (2015) Synthesis of Chitosan Coated Iron Oxide (Fe3O4) Nanoparticles by Electrochemical Method. BTech thesis.

  • Microwave-driven Synthesis of Iron Oxide Nanoparticles …

    29. Berman SMC, Walczak P, Bulte JWM. Tracking stem cells using magnetic nanoparticles. 2011;3:343-55

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magnetic iron oxide nanoparticles | Nanoparticle | Iron

In another interesting work, Louie and coworkers have reported the synthesis of a reversible T2 contrast agent that is capable of modulating the relaxation time in response to light irradiation []. A spiropyran (SP) derivative that changes conformation between hydrophilic and hydrophobic isomers in response to light, has been covalently attached to dextran sulfate coated iron oxide nanoparticles (ADIO). The light induced reversible aggregation of MNPs has been found to modulate the T2 relaxation time (Figure ).

the Preparation Techniques of Iron Oxide ..

Fe2O3 nanoparticles were purchased from Alfa Aesar. Fe/Fe oxide nanoparticles were synthesized by reduction of aqueous solutions of FeCl3 within a NaBH4 solution, with or without the presence of a micro-emulsion. For synthesis of Fe/Fe oxide nanoparticle without a micro-emulsion, a typical procedure (carried out in an inert atmosphere or in aerobic conditions, at room temperature and ambient pressure) was started with dropwise addition of NaBH4 into a vigorously stirred FeCl3 solution. At the beginning of the reaction, the solution turned to a blackish color due to the precipitation of particles. The precipitates were washed with de-ionized (DI) water and acetone. Prior to use, DI water and acetone were purged with Ar for several hours to get rid of the oxygen. Anhydrous FeCl3 purchased from Alpha Aesar was stored in glove box until used. Aqueous solutions of FeCl3 were prepared immediately before nanoparticle synthesis using prepurged DI water.

Synthesis of Iron Oxide Nanoparticles Using …

(a) Proposed mechanism of reversible aggregation. (b) Preparation of cross linked dextran sulfate coated iron oxide nanoparticles (CLADIO), functionalized with amine groups and spiropyran (SP). Reproduced with permission with from Ref. []. Copyright (2010) American Chemical Society.

Hybrid gold-iron oxide nanoparticles as a …

This paper describes a sol−gel approach for the coating of superparamagnetic iron oxide nanoparticles with uniform shells of amorphous silica. The coating process has been successfully applied to particles contained in a commercial ferrofluid (e.g., the EMG 304 of Ferrofluidics) and those synthesized through a wet chemical process. The thickness of silica coating could be conveniently controlled in the range of 2−100 nm by changing the concentration of the sol−gel solution. Fluorescent dyes, for example, 7-(dimethylamino)-4-methylcoumarin-3-isothiocyanate (DACITC) and tetramethylrhodamine-5-isothiocyanate (5-TRITC), have also been incorporated into the silica shells by covalently coupling these organic compounds with the sol−gel precursor. These multifunctional nanoparticles are potentially useful in a number of areas because they can be simultaneously manipulated with an externally applied magnetic field and characterized in situ using conventional fluorescence microscopy.

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