Call us toll-free

pulegone 15932-80-6 - The Good Scents Company

Menthol - Wikipedia

Approximate price


275 Words


European information : Most important hazard(s): Xn - Harmful

TRPV3 is a sensitizing receptor (; ), such that upon prolonged or repeated stimulation, currents evoked by chemical or thermal stimuli increase in amplitude. The synthetic TRPV3 agonist, 2-aminoethoxy diphenyl borate (2-APB), which is structurally unrelated to camphor, has been shown to activate significant currents upon first application at concentrations of 100–300μ. In contrast, camphor as a relatively weak agonist, activates sizeable currents only at concentrations of 10m or higher on first exposure. However, after preceding stimulation with higher doses, pronounced currents can already be observed with 2m camphor. Also, camphor's dose dependence is shifted to lower activating concentrations after prestimulating exposures to 2-APB before camphor treatment ().

R 36/38 - Irritating to skin and eyes

For the identification and characterization of new TRPV3 agonists, the activity of 33 monoterpenes and related compounds on TRPV3 was compared to that of camphor. Screening was performed by whole-cell patch-clamp measurements of HEK293 cells expressing murine TRPV3. The tested compounds were grouped with respect to structural similarity: Twelve bicyclic monoterpenes were tested, including the known agonist camphor and its biosynthetic precursor (+)-borneol. The monocyclic monoterpenes as the largest group were divided into eight aromatic and nine non-aromatic compounds. In addition, three related cyclic compounds not classified as monoterpenes, among them the sesquiterpene (−)-α-bisabolol as well as two acyclic monoterpenes were tested.

Toronto Research Chemicals - TRC Canada

2,6-xylenol, 576-26-1 - The Good Scents Company

We therefore examined a number of terpenoid compounds in which different structural elements were systematically varied to identify features required for channel activation. Out of the 33 tested terpenes and related compounds, six agonists significantly stronger than camphor were identified. All of these activate TRPV3 with an EC50 substantially lower than that of camphor and the two most potent ones – 6-tert-butyl-m-cresol and carvacrol, also show a higher potency than the synthetic agonist 2-APB.

To examine TRPV3 activation by these compounds in more detail, dose–response curves were created. This was done in Xenopus oocytes, as TRPV3 is known to show no apparent sensitization in this system (; ), making the comparison of elicited current amplitudes more reliable. Typical recordings are shown in . Camphor activated TRPV3 with an EC50 of about 6m (see ). The synthetic agonist 2-APB was also tested and showed an EC50 of 0.515±0.005m, which is in fair agreement with an EC50 of 1.06m reported by others ().

HSN codes for organic chemicals - HOW to Export …

The information provided below about HSN codes are used for GST purpose to classify goods

50 Years Of Flavor Chemistry - SlideShare
Order now
  • synthesis of thymol? | Yahoo Answers

    Menthol is an organic compound made synthetically or obtained from corn mint, peppermint, or other mint oils

  • Menthols | Toxicity | Chemistry

    Phenols - Wikipedia

  • D/L-menthol is produced via reaction of m-cresol with ..

    R 22 - Harmful if swallowed

Order now
  • Kim

    "I have always been impressed by the quick turnaround and your thoroughness. Easily the most professional essay writing service on the web."

  • Paul

    "Your assistance and the first class service is much appreciated. My essay reads so well and without your help I'm sure I would have been marked down again on grammar and syntax."

  • Ellen

    "Thanks again for your excellent work with my assignments. No doubts you're true experts at what you do and very approachable."

  • Joyce

    "Very professional, cheap and friendly service. Thanks for writing two important essays for me, I wouldn't have written it myself because of the tight deadline."

  • Albert

    "Thanks for your cautious eye, attention to detail and overall superb service. Thanks to you, now I am confident that I can submit my term paper on time."

  • Mary

    "Thank you for the GREAT work you have done. Just wanted to tell that I'm very happy with my essay and will get back with more assignments soon."

Ready to tackle your homework?

Place an order