T1 - Synthesis of CdSe quantum dots
T1 - Synthesis of CdTe-CdSe core-shell quantum dots with luminescence in the red
CdSe Quantum Dots synthesis - YouTube
AB - This paper reports the synthesis of highly lumimescence CdSe quantum dots via wet-chemical process and the study of the surfactant concentration effect on the improvement of the photoluminescence characteristic. Here, we also discussed in detail the quantum dots synthesis procedure and the mechanism for the improvement of the luminescence characteristic of CdSe quantum dots under a different surfactant concentration.
In this laboratory, students will study how surfactant-based chemistry can be used to synthesize CdSe quantum dots and study how the size of the quantum dots can be controlled by varying reaction time. The laboratory will demonstrate how the color of these quantum dots can be connected to the size of the nanoparticle by considering the electrons as freely moving particles in a box with the dimensions of the nanoparticle. The model of will be compared with more exact results, and use this to create a calibration curve. Students will be able to estimate the size of quantum dots by using UV-VIS absorption spectroscopy
Synthesis of CdSe/ZnS and CdTe/ZnS Quantum Dots: …
Wu et al. reported polysaccharide-based hybrid nanogels that combine functional building blocks for optical pH-sensing, cancer cell imaging, and controlled drug release within a single nanoparticle system for combined diagnosis and therapy. The hybrid nanogels were synthesized by in-situ immobilization of CdSe QDs in the interior of the dual responsive (pH and temperature) hydroxypropylcellulose -poly (acrylic acid) (HPC-PAA) semi-interpenetrating polymer networks. The HPC-PAA-CdSe hybrid nanogels combine a strong trap emission at 741 nm for sensing physicochemical environment in a pH dependent manner and a visible excitonic emission at 592 nm for mouse melanoma B16F10 cell imaging. The hybrid nanogels also provide excellent stability as a drug carrier. They not only provide a high drug loading capacity for a model anticancer drug, temozolomide, but also offer a pH-triggered sustained-release of the drug molecules in the gel network.
Mahajan et al have used an attractive approach where drug delivery has been integrated with site-specificity using a QD-based platform . Specifically, the antiretroviral drug saquinavir and the biorecognition molecule transferrin (Tf) have been conjugated to carboxyl-terminated quantum dots using carbodiimide chemistry. The aim of this study was to significantly enhance the transport of saquinavir into the brain, for the treatment of HIV-1 infected cells within the brain, via targeting the transferrin receptors (TfRs), which are overexpressed on the apical surface of the blood brain barrier (BBB). Using an model of the BBB, they demonstrated that these targeted and drug-doped QDs can efficiently cross the BBB, and caused a marked decrease in viral replication in the HIV-1 infected peripheral blood mononuclear cells (PBMCs) within the brain. These results highlight the potential of this nanoformulation in the treatment of Neuro-AIDS and other neurological disorders.
Synthesis of Cadmium Selenide Quantum Dot ..
We have shown the utility of quantum dot (QD)-siRNA complexes in maintaining the integrity of the blood brain barrier (BBB) (see Figure ). The matrix-degrading metalloproteinases (MMPs), particularly MMP-9, are involved in neuroinflammation processes leading to disrupting of the BBB, thereby exacerbating neurological diseases such as HIV-1 AIDS dementia and cerebral ischemia. We evaluated the specificity and efficiency of QD complexed with MMP-9-siRNA (nanoplex) in downregulating the expression of MMP-9 in brain microvascular endothelial cells (BMVECs) that constitute the BBB. Silencing MMP-9 gene expression in BMVECs and other cells such as leukocytes may help prevent breakdown of the BBB and inhibit subsequent invasion of the central nervous system (CNS) by infected and inflammatory cells, as well as circulating neurotoxins. Several other groups have also demonstrated the significance of QD/QR mediated delivery of siRNA molecules for the treatment of a variety of ailments, particularly cancer.
Apart from the delivery of conventional, small molecule drugs, quantum dots/rods have also been shown to have promise for delivery of more complex biomolecules, such as short interfering RNA (siRNA). These short and double-stranded therapeutic RNA molecules function by blocking the expression of undesirable, disease-causing genes. However, in their free form they have high negative charge and are vulnerable to degradation in physiological fluids. Therefore, for optimal function and vivo, they must be delivered via electrostatic complexation with cationic nanocariers. Quantum dots/rods, appropriately surface functionalized with cationic moieties, are ideal siRNA carriers as they not only render these genetic drugs with physiological stability and target specificity, but also the whole complex (nanoplex) can be optically traced.
SYNTHESIS OF ULTRA-SMALL CdSe QUANTUM DOTS
CdTe and CdSe quantum dots: synthesis, …
26/7/2012 · CdSe Quantum Dots synthesis - Duration: 10:42
the synthesis of highly luminescent quantum dots ..
"A Safer, Easier, Faster Synthesis for CdSe Quantum Dot Nanocrystals ..
Synthesis of CdSe/ZnS and CdTe/ZnS Quantum Dots ..
CdTe and CdSe quantum dots: synthesis, characterizations and applications ..
Room Temperature Synthesis of CdSe Quantum Dots…
72. Liu W, Choi HS, Zimmer JP, Tanaka E, Frangioni JV, Bawendi M. Compact Cysteine-Coated CdSe(ZnCdS) Quantum Dots for in Vivo Applications. 2007;129:14530-1
Synthesis of CdSe quantum dots decorated SnO2 …
70. Erogbogbo F, Yong K-T, Roy I, Xu G, Prasad PN, Swihart MT. Biocompatible Luminescent Silicon Quantum Dots for Imaging of Cancer Cells. 2008;2:873-8
For example, in CdSe quantum dots, ..
69. Dubertret B, Skourides P, Norris DJ, Noireaux V, Brivanlou AH, Libchaber A. In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles. 2002;298:1759-62 doi:10.1126/science.1077194
Confined synthesis of CdSe quantum dots in the pores …
68. Larson DR, Zipfel WR, Williams RM, Clark SW, Bruchez MP, Wise FW. . Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo. 2003;300:1434-6 doi:10.1126/science.1083780
Organometallic Synthesis Kinetics of CdSe Quantum Dots
67. Jiang W, Mardyani S, Fischer H, Chan CW. Design and Characterization of Lysine Cross-Linked Mercapto-Acid Biocompatible Quantum Dots. 2006;18:872-8
Synthesis and spectroscopic studies of chiral CdSe quantum dots
61. Courty S, Bouzigues C, Luccardini C, Ehrensperger M, Bonneau S, Dahan M. . Tracking Individual Proteins in Living Cells Using Single Quantum Dot Imaging. 2006:211-28
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