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Thus, either could be responsible for chronic hepatotoxic effects.

The results suggest that calcium chelation may be a mechanism of therapeutic action in chemically-induced hepatotoxicity.

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PubMed/NCBI - National Center for Biotechnology …

(Extensive review of the literature on hepatotoxicity of antituberculosis medications in children concluded that liver injury occurs in children with isoniazid, pyrazinamide and rifampin, but at a lower rate than in adults).

However, review cautions use of the herb because of reported hepatotoxicity.

There was, however, a relationship between delay in treatment and the risk of hepatotoxicity, as judged by liver function tests in patients in whom plasma paracetamol concentrations indicated a likelihood of hepatotoxicity.

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A possible consequence of the enhancement of isoniazid hepatotoxicity by enzyme induction.

Risk factors for hepatotoxicity associated with rifampin and pyrazinamide for the treatment of latent tuberculosis infection: experience from three public health tuberculosis clinics.

(Among 1200 kidney transplants, 45 [4%] developed tuberculosis after transplant, usually after several years, all treated with isoniazid, rifampin and ethambutol; hepatotoxicity in 11 [25%], but severe in only 3 and all responded to withdrawal of isoniazid or rifampin or both).

Disposition and hepatotoxicity of 1,2-dibromoethane - …

[Hepatotoxicity of rifampicin and isoniazid in the treatment of tuberculous meningitis].

(Retrospective questionnaire survey regarding 874 children treated with isoniazid and rifampin for active tuberculosis identified 68 [7.6%] adverse reactions including hepatotoxicity in 16 (1.7%], including 2 attributed to isoniazid, 12 to rifampin and 2 to the combination; hepatitis rates being 0.5% for isoniazid and 3.2% for rifampin; half during first month, 75% within 10 weeks, only risk factor identified was severe disease for rifampin hepatotoxicity; recommended monitoring during therapy).

(Report from Birmingham coroner of 3 cases of fatal hepatotoxicity in patients on isoniazid, rifampin and pyrazinamide; frequently had symptoms for several weeks before stopping antituberculosis therapy).

Acetylation phenotype and hepatotoxicity in the treatment of tuberculosis in children.
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  • Acetaminophen-Induced Hepatotoxicity - PRIME …

    Hepatotoxicity in rifampin-isoniazid treated patients related to their rate of isoniazid inactivation.

  • A+ drug related hepatotoxicity navarro | OnlineDrug☀

    An analysis of 572 cases of hepatotoxicity reported to the Danish Board of Adverse Reactions to Drugs.

  • Novel human in vitro systems for studies of drug …

    Hepatotoxicity of antituberculosis therapy(rifampicin, isoniazid and pyrazinamide) or viral hepatitis.

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The work presented in this thesis aimed to refine and ..

Hepatotoxicity in patients co-infected with tuberculosis and HIV-1 while receiving non-nucleoside reverse transcriptase inhibitor-based antiretroviral therapy and rifampicin-containing anti-tuberculosis regimen.

PubMed/NCBI - National Center for Biotechnology Information

(Among 218 patients with tuberculosis started on therapy who underwent genetic testing, hepatotoxicity was more frequent among slow-acetylators [NAT2] and with certain polymorphisms of CYP 2E1).

Drug and alcohol induced hepatotoxicity

Tee LBG, Davies DS, Seddon CE, & Boobis AR (1987) Species differences in the hepatotoxicity of paracetamol are due to differences in the rate of conversion to its cytotoxic metabolite.

do summaries have thesis statements Doctoral ..

(Among 144 patients with tuberculosis undergoing treatment, hepatotoxicity was more frequent in slow acetylators, although the severity of the injury did not correlate with any genetic polymorphism tested).

cystamine treatment of chemically-induced hepatotoxicity

Wong LT, Whitehouse LW, Solomonraj G, & Paul CJ (1980) Effect of concomitant single dose of ethanol on the hepatotoxicity and metabolism of acetaminophen in mice.

Metabolism and hepatotoxicity of morphine, codeine …

(Analysis of pooled data from 3586 patients in published reports on efficacy and safety of 4 months of rifampin and 9 months of isoniazid as therapy of latent tuberculosis indicated that hepatotoxicity was less common with rifampin [0-0.7%] than isoniazid [1.4-5.2%]).

Metabolism and hepatotoxicity of morphine, codeine and pholcodeine

There is also evidence of increased hepatotoxicity when methionine is given to mice with liver failure induced experimentally by carbon tetrachloride, but not if induced by paracetamol.

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