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Disseminated Intravascular Coagulation — NEJM



Bentham Science Publishers is rendering a vital service in the quality publication that publishes over 100 peer-reviewed print and online scientific, technical and medical journals. These titles are indexed in recognized indexing agencies, such as Science Citation Index®, Journal Citation Reports/Science Edition, MEDLINE/Index Medicus, PubMed, Scopus, Chemical Abstracts, EMBASE etc. Some of the high impact titles which enjoy a wide reach and distribution are Current Gene Therapy (Impact Factor 4.906), Current Alzheimer Research (Impact Factor 3.796), Current Medicinal Chemistry (Impact Factor 3.715), and other popular titles.

Bentham has an extensive library of eBooks in the areas of science, technology, medicine, social sciences and humanities. Bentham eBooks publishes monographs, handbooks, conference proceedings, textbooks, review volumes, biographies and autobiographies.

In demographics, the world population is the total number of humans currently living

Jonathan Bisson obtained an M.S. degree in Structural Biochemistry and started his phytochemistry journey under the mentorship of Dr. Vincent Dumontet at the Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France. He then obtained a Ph.D. in Science, Technology and Health from the University of Bordeaux, France under the mentorship of Dr. Pierre Waffo-Téguo, specializing in methodology at the chemistry–biology interface. In 2013, he joined the University of Illinois at Chicago, where he is currently a Postdoctoral Research Associate, developing new methods and tools for natural products research in interdisciplinary programs, mainly through data analysis, NMR, and chromatographic approaches related to promiscuous natural products (IMPS). Recently, he has been involved in the redesign of the NAPRALERT database.

Ross Mckinnon - Flinders University

Home Page ::: Current Organic Synthesis

Domenico Russo is the Industrial & Process Development Chemist Manager at BIAL - Portela & Cª, S.A., after obtaining his Ph.D. degree in organic chemistry at the University of Catania (Italy) he worked in the R&D department and API manufacturing animal health division ofat Wyeth lederle Italy from 1996 to 2008.

He has over 18 years experience in drug substance process development and relevant industrialization at full manufacturing scale. During this time, he held various positions within medium to large pharma companies in different phases of drug development. In his current position at Bial S.A. Domenico has played a key role in the successful process development of new chemical entities by technology process transfer alongside comprehensive GMP CRO qualification processes. This drug development experience ranges from early development to phase III development as well as lifecycle activities support for approved drugs. He is also supporting reliable supply chain and market authorization process of new drug product through a multidisciplinary project team environment. Domenico has a keen interest in training and development, sharing best practices and standardizing processes across development and industrialization research project management function. Apart from drug substance development, Domenico has a strong interest in the management of innovation, innovation processes and the organizational factors impacting creativity and innovation.

The binding of calcium ion is essential to allow the activation of these proteins.
Within the cell, vitamin K epoxid (oxidized) is reduced to vitamin K hydroquinone by the enzyme vitamin K epoxide reductase (VKOR).
The reduction and subsequent reoxidation of vitamin K coupled with carboxylation of Glu is called vitamin K cycle.
Warfarin and other 4-hydroxycoumarins block the action of the This results in decreased concentrations of vitamin K and vitamin K hydroquinone in the tissues, such that the carboxylation reaction catalyzed by the glutamyl carboxylase is inefficient.
Regarding the coagulation, vitamin K is important for the hepatic synthesis of coagulation factors II (prothrombin), X (clotting factors), and protein C with his cofactor protein S (endogenous anticoagulants).

Oral anticoagulants exert their effect by blocking the utilization of vitamin K.

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