Thieme Medical Publishers - Journals
Main Text Introduction
Disseminated Intravascular Coagulation — NEJM
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Jonathan Bisson obtained an M.S. degree in Structural Biochemistry and started his phytochemistry journey under the mentorship of Dr. Vincent Dumontet at the Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France. He then obtained a Ph.D. in Science, Technology and Health from the University of Bordeaux, France under the mentorship of Dr. Pierre Waffo-Téguo, specializing in methodology at the chemistry–biology interface. In 2013, he joined the University of Illinois at Chicago, where he is currently a Postdoctoral Research Associate, developing new methods and tools for natural products research in interdisciplinary programs, mainly through data analysis, NMR, and chromatographic approaches related to promiscuous natural products (IMPS). Recently, he has been involved in the redesign of the NAPRALERT database.
Ross Mckinnon - Flinders University
Domenico Russo is the Industrial & Process Development Chemist Manager at BIAL - Portela & CÂª, S.A., after obtaining his Ph.D. degree in organic chemistry at the University of Catania (Italy) he worked in the R&D department and API manufacturing animal health division ofat Wyeth lederle Italy from 1996 to 2008.
He has over 18 years experience in drug substance process development and relevant industrialization at full manufacturing scale. During this time, he held various positions within medium to large pharma companies in different phases of drug development. In his current position at Bial S.A. Domenico has played a key role in the successful process development of new chemical entities by technology process transfer alongside comprehensive GMP CRO qualification processes. This drug development experience ranges from early development to phase III development as well as lifecycle activities support for approved drugs. He is also supporting reliable supply chain and market authorization process of new drug product through a multidisciplinary project team environment. Domenico has a keen interest in training and development, sharing best practices and standardizing processes across development and industrialization research project management function. Apart from drug substance development, Domenico has a strong interest in the management of innovation, innovation processes and the organizational factors impacting creativity and innovation.
The binding of calcium ion is essential to allow the activation of these proteins.
Within the cell, vitamin K epoxid (oxidized) is reduced to vitamin K hydroquinone by the enzyme vitamin K epoxide reductase (VKOR).
The reduction and subsequent reoxidation of vitamin K coupled with carboxylation of Glu is called vitamin K cycle.
Warfarin and other 4-hydroxycoumarins block the action of the This results in decreased concentrations of vitamin K and vitamin K hydroquinone in the tissues, such that the carboxylation reaction catalyzed by the glutamyl carboxylase is inefficient.
Regarding the coagulation, vitamin K is important for the hepatic synthesis of coagulation factors II (prothrombin), X (clotting factors), and protein C with his cofactor protein S (endogenous anticoagulants).
Oral anticoagulants exert their effect by blocking the utilization of vitamin K.
Thieme E -Books & E-Journals ..
Thieme E-Books & E -Journals
SYNLETT is published 20 times ..
Synthesis - SCImago Journal Rank
Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders
SYNTHESIS is a journal of international character devoted to the ..
Energy Biosciences Institute
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