The “two-hit” hypothesis is the ..
Progression of NAFLD to NASH has been modeled by a “2-hit” hypothesis  .
the multiple parallel hits hypothesis.
One global hypothesis for the pathogenesis of NASH is the “multi-hit hypothesis,” with metabolic syndrome playing a major role, due to insulin resistance and the proinflammatory process mediated by different proteins and immune components. The identities of the multiple “hits” are different in each patient and largely undefined at present.
For this reason, the initial ‘two-hit’ theory for explaining the progression from NAFLD to NASH is now being modified by the ‘multiple parallel hits’ hypothesis.
of the “two-hit” hypothesis in explaining ..
Hepatocellular carcinoma is a well-recognized complication of NASH related cirrhosis.1Several systems have been proposed for the histologic assessment of NAFLD, of which the Kleiner NAFLD activity score (NAS) is probably the most well established . The pathogenesis of NAFLD for long has been explained by the two hit theory.
Parallel Hits” Hypothesis of NAFLD.
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