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Green Synthesis of Metallic Nanoparticles via ..

Synthesis and Characterization of Silver Substituted Hydroxyapatite Nanopowders: ..

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Journal of Nanoscience and Nanotechnology



In this study, Cupper, silver and eurobium are selected to use as a substitution materails.


Characterization of Cu/Ag/ Eu/ Hydroxyapatites Composites by Using Wet Chemical Precipitation



Marmara University, Faculty of Engineering, Bioengineering Department, Istanbul

Bioengineering Department of Marmara University

Summer Intership in the Faculty of Applied Chemistry and Material Science in Politehnica University of Bucharest
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FTIR spectra of different concentration of all substituted HA
SEM images of different concentrations substituted HA
In the present study, we contributed to study of the influence of the varying concentration of Copper, Silver and Europium substituted hydroxyapatite were synthesized by wet chemical method.

PDF Downloads : Oriental Journal of Chemistry

Hydroxyapatite plays a key role in bioceramic and biomaterial composites and is commonly used in reconstruction medicine and dental implantology. However, we can observe a trend of a broadening of the spectrum of the apatite materials, with additional biological, physicochemical, or biomechanical properties, despite the scaffold for the newly formed bone. It seems very reasonable to look for the possibility of the substitution of ions with antibacterial properties. So far, the best-known and most commonly used material is hydroxyapatite enriched with silver ions. Much is also known about the antibacterial activity of hydroxyapatites substituted by the ions of copper and zinc. On the other hand, it seems that the other materials still require a great deal of research. In our opinion, one should also examine the relationship between the method of the preparation of the substituted apatite material with its antibacterial activity and its efficiency. Such studies remain very rare or else incomplete.

MATERIALS FOCUS - American Scientific Publishers

Synthesis, characterization and modelling of zinc and silicate co-substituted hydroxyapatite Journal of The Royal Society Interf

Reconstructive surgery is presently struggling with the problem of infections located within implantation biomaterials. Of course, the best antibacterial protection is antibiotic therapy. However, oral antibiotic therapy is sometimes ineffective, while administering an antibiotic at the location of infection is often associated with an unfavourable ratio of dosage efficiency and toxic effect. Thus, the present study aims to find a new factor which may improve antibacterial activity while also presenting low toxicity to the human cells. Such factors are usually implemented along with the implant itself and may be an integral part of it. Many recent studies have focused on inorganic factors, such as metal nanoparticles, salts, and metal oxides. The advantages of inorganic factors include the ease with which they can be combined with ceramic and polymeric biomaterials. The following review focuses on hydroxyapatites substituted with ions with antibacterial properties. It considers materials that have already been applied in regenerative medicine (e.g., hydroxyapatites with silver ions) and those that are only at the preliminary stage of research and which could potentially be used in implantology or dentistry. We present methods for the synthesis of modified apatites and the antibacterial mechanisms of various ions as well as their antibacterial efficiency.

Despite the fact that HA has poor mechanical qualities and doesn’t have antimicrobial properties, its poor mechanical properties can be improved and obtained antimicrobial properties by adding diverse oxides, ions and metal or non-metal.


Due to the flexibility in the structure of the hydroxyapatite, the various ions such as silver, zinc, bismuth, copper, strontium, silicate and carbonate are substituted in hydroxyapatite to improve the properties such as antibacterial property, mechanical strength and solubility for bone implantation.

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Na Zhang, Dong Zhai, Lei Chen, Zhaoyong Zou, Kaili Lin*, Jiang Chang*, Hydrothermal synthesis and characterization of Si and Sr co-substituted hydroxyapatite nanowires using strontium containing calcium silicate as precursors, Materials Sciences and Engineering C, 2014, 37: 286–291.

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  • 29/01/2004 · Original Article

    - MDPI

  • Development of nanosized silver-substituted apatite for ..

    Oriental Journal of Chemistry is a peer reviewed quarterly research journal of pure and applied chemistry

  • Zinc-substituted hydroxyapatite nanoparticles synthesized by ..

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